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First-line treatment with infliximab versus conventional treatment

Posted: January 31 2021

Abstract Objective In newly diagnosed paediatric patients with moderate-to-severe Crohn’s disease (CD), infliximab (IFX) is initiated once exclusive enteral nutrition (EEN), corticosteroid and immunomodulator therapies have failed. We aimed to investigate whether starting first-line IFX (FL-IFX) is more effective to achieve and maintain remission than conventional treatment. Design In this multicentre open-label randomised controlled trial, untreated patients […]

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News

Gut mi­cro­bi­ota re­veals whether drug ther­apies work in in­flam­mat­ory bowel dis­eases

Posted: January 28 2021

The prevalence of inflammatory bowel diseases has significantly increased both in Finland and globally. These disorders cannot be entirely cured. Instead, they are treated with anti-inflammatory drugs and, at times, through surgery. If conventional drug therapies based on anti-inflammatory drugs are ineffective, the diseases can be treated using infliximab, a biological TNF-α blocker that is […]

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Blog

Tips for surviving your first PillCam

Posted: January 25 2021

By Jenna Farmer Although inflammatory bowel disease (IBD) isn’t a new condition, the scientific developments surrounding it are constantly changing. Along with new treatments, new procedures have also been created to help with the diagnostic and monitoring process of IBD patients. One of these is a PillCam, a nifty piece of technology that’s particularly useful for those […]

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Research

Early assessment with gastrointestinal ultrasound in patients hospitalised for a flare of ulcerative colitis

Predicting the need for salvage therapy: a pilot study

Approximately 30% of patients hospitalised with severe ulcerative colitis do not respond to corticosteroids, but the decision to introduce salvage therapy is delayed to at least the third day of treatment, according to the widely applied Oxford criteria to assess response. This pilot study aimed to determine if gastrointestinal ultrasound performed on admission can predict […]

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Blog

Sugar may trigger inflammatory bowel disease by breaking down gut mucus

Posted: January 20 2021

By Madeline Barron When I was seventeen, I discovered that I could make s’mores in the microwave. The recipe was simple: slam a marshmallow on to a graham cracker, heat for 20 seconds, and let it balloon. This occasional summer treat soon became a daily indulgence. My inflammatory bowel disease (IBD) diagnosis soon followed.  IBD […]

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Research

Vitamin D modulates intestinal microbiota in inflammatory bowel diseases

The main micronutrient deficiencies observed in patients with IBD are zinc, iron, vitamin B12, and vitamin D, contributing to a critical condition and influencing on well-being.

Inflammatory bowel disease (IBD) is a chronic inflammation of the gastrointestinal tract (GIT), including Crohn’s disease (CD) and ulcerative colitis (UC), which differ in the location and lesion extensions. Both diseases are associated with microbiota dysbiosis, with a reduced populationof butyrate-producing species, abnormal inflammatory response, and micronutrient deficiency (e.g., vitamin D hypovitaminosis). Vitamin D (VitD) […]

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