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The latest news and Research

News

Surgery risk for IBD declining in biologic era, ‘but that doesn’t mean it’s zero’

Posted: January 24 2022

By Robert Stott “If you think in terms of risk, about what the most disabling situation is when it comes to ulcerative colitis, it’s probably surgery, and most patients would like to avoid this at any cost,” Angelina Collins, MSN, ANP‐BC, from the Inflammatory Bowel Disease Center at UC San Diego Health, told attendees. “There is […]

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Research

Research links gut fungi to intestinal inflammation in Crohn’s disease

Results of a new study by researchers at Case Western Reserve University represent a step toward improving our understanding of Crohn’s disease and the factors that cause its intestinal inflammation.

Crohn’s disease is a type of inflammatory bowel disease that can lead to chronic inflammation of the entire digestive tract. Symptoms include diarrhea, pain and cramping, fatigue, weight loss and more. There is no cure for Crohn’s disease, but patients can alleviate symptoms with current treatment options.    New treatment options for Crohn’s disease patients […]

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Personal Story

What I wish people knew about ulcerative colitis

Posted: January 20 2022

By Nour Al-Timimi Not too long ago, perhaps a few weeks ago, I was telling a colleague how I don’t like describing an unfamiliar person by their physical features. I obviously don’t know them enough to be able to describe them by personality or character trait, which makes it difficult when speaking or referring to […]

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News

People with IBD have more microplastics in their feces

Posted: January 13 2022

Microplastics — tiny pieces of plastic less than 5 mm in length — are everywhere, from bottled water to food to air. According to recent estimates, people consume tens of thousands of these particles each year, with unknown health consequences.  The prevalence of IBD, which includes Crohn’s disease and ulcerative colitis, is rising globally. Characterized […]

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News

Global spread of autoimmune disease blamed on western diet

Posted: January 10 2022

By Robin McKie  More and more people around the world are suffering because their immune systems can no longer tell the difference between healthy cells and invading micro-organisms. Disease defences that once protected them are instead attacking their tissue and organs. Major international research efforts are being made to fight this trend – including an initiative at […]

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Research

First structure of human protein complex with ‘licence to kill’

A team of WEHI researchers has for the first time visualised a human cell death complex linked to autoimmune and inflammatory conditions, such as inflammatory bowel disease, and injuries associated with excessive cell death.

Using the Australian Synchrotron, the team solved the structure of the human cell death proteins MLKL and RIPK3 bound to each other, as well as human RIPK3 alone. When RIPK3 activates MLKL, it triggers a type of inflammatory cell death called necroptosis that kills the cell and alerts the immune system that it is under attack. However, […]

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