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Study reveals genetic and cellular mechanisms of Crohn’s disease

Posted: April 14 2021

Mount Sinai researchers have identified genetic and cellular mechanisms of Crohn’s disease, providing new insights for future treatments that could offer a tailored approach to patients with the chronic inflammatory disease, according to a study published in Nature on March 31. The researchers found that blocking the common cytokine receptor subunit gp130 may benefit some patients with […]

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Research

Towards a toolbox for à la carte editing of the human microbiome

Insights from bacteria-infecting viruses could vastly improve genome editing in diverse microbes, including those of the human microbiome.

By Gabriel Filsinger and Benjamin Boettner The number of bacterial cells inside each person is approximately equal to the number of human cells in the body. Interestingly, how these bacteria contribute to our health or to disease is still largely a mystery. Research on the human microbiome, the bacterial collective inhabiting our gut and other […]

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News

New potential therapy for Crohn’s disease in children

Posted: February 24 2021

Scientists from the Stanley Manne Children’s Research Institute at Ann & Robert H. Lurie Children’s Hospital of Chicago demonstrated that a nanotherapy reduces intestinal inflammation and shrinks lesions in a rodent model of severe Crohn’s disease. This approach could become an alternative to biologic antibody therapies that carry many side effects, including increased risk of certain cancers. […]

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Blog

Questions people with ulcerative colitis may have about biologics

Posted: February 18 2021

By Korin Miller For some people with ulcerative colitis, biologics are important for managing many painful symptoms, like diarrhea, abdominal pain, and fevers. First, here’s a little refresher on why these symptoms occur in the first place. Ulcerative colitis, an inflammatory bowel disease, causes inflammation and ulcers in your colon and rectum; your specific symptoms may vary depending on where […]

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Personal Story

Teen’s Crohn’s treatment helps her keep playing music

Posted: December 1 2020

For Abigail Tucker, it started with migraines and stomach pains. Then she started losing weight — as much as 50 pounds. She said her condition worsened to the point that, when she was 13, she felt like withdrawing from friends and skipping activities such as playing or teaching piano. Soon she was often missing a […]

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