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A T-cell stimulatory protein and interleukin-10 synergize to prevent gut inflammation

Researchers have found an unexpected synergy between a T-cell stimulatory protein — the ICOS ligand — and interleukin-10, an immunoregulatory cytokine, to prevent inflammatory bowel disease in mice.

The study will aid the understanding of, and future research into, this immune disorder, which includes Crohn’s disease and ulcerative colitis. Interleukin-10, or IL-10, was already known as a major player to prevent gut inflammation by establishing and maintaining immune homeostasis in the gut, where it is vital for the host to have a peaceful […]

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News

Crohn’s disease may develop from warped immune cell signalling during bile acid exposure

Posted: April 13 2021

People with Crohn’s disease are typically treated with powerful anti-inflammatory medications that act throughout their body, not just in their digestive tract, creating the potential for unintended, and often serious, side effects. New research from the lab of Mark Sundrud, PhD, at Scripps Research, Florida suggests a more targeted treatment approach is possible. Crohn’s disease develops […]

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Research

Opening a new door into kinder, gentler therapies for chronic inflammation

A naturally occurring antibody capable of stimulating the body's immune-suppressing regulatory T cells has been discovered by a team of Harvard scientists.

Biologic treatments that have been developed over the past quarter-century have proved to be game-changers, but the drugs are imperfect and leave some patients vulnerable to opportunistic infections, and in rare instances, cancers of the blood. Clearly, there is room for improvement, immunologists worldwide contend. The newly identified antibody is noteworthy because of its activity […]

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