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Sarcopenia and vitamin D deficiency in patients with Crohn’s disease: Pathological conditions that should be linked together

Sarcopenia is a prevalent condition in patients with Crohn’s disease (CD), representing an independent predictor factor for the development of major postoperative complications.

Excerpt: Introduction Crohn’s disease (CD) is a chronic and progressive inflammatory bowel disease (IBD) that has a high impact on a patient’s quality of life. It is well known that all segments of the gastrointestinal tract can be affected by CD, mainly the terminal ileum and colon. Inflammation is generally segmental, asymmetrical, and transmural. Although […]

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Research

Defects in a specific cell type may cause ulcerative colitis

There are many variants of "goblet cells" in the intestines and they seem to have different functions, according to a new study from the University of Gothenburg.

The entire inside of our intestines is covered by a thin layer of mucus that protects the fragile mucous membrane (mucosa) from bacteria and other microorganisms. If the microorganisms repeatedly come into contact with the intestinal mucosa, inflammation and even cell changes may result. These increase the risk of intestinal cancer. In a healthy colon, […]

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News

Crohn’s disease in Australia – the latest research

Posted: March 2 2021

Research Scientist and Paediatric Gastroenterologist Dr Ed Giles and Associate Professor Rebecca Lim are both leading research into Crohn’s at Hudson Institute. Dr Ed Giles is leading two Crohn’s studies at Hudson Institute. One is investigating the relationship between the microbiome and Crohn’s. The other is examining our immune system response and its relationship to inflammation […]

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Research

Greenspace exposure during childhood reduces risk for IBD

Childhood exposure to residential greenspace was associated with a reduced risk for inflammatory bowel disease, according to data published in the American Journal of Gastroenterology.

By Monica Stonehill “Intervention studies designed to target specific environmental risk factors to reduce the risk of IBD should include greenspace in study design,” Michael Elten, MSc, from the School of Epidemiology and Public Health, University of Ottawa in Canada, and colleagues wrote. “It is possible that by changing our immediate environment, we could prevent childhood-onset IBD.” Elten and colleagues […]

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News

Surgery to heal inflamed gut may create new target for disease

Posted: February 4 2021

A surgical procedure meant to counter ulcerative colitis, an immune disease affecting the colon, may trigger a second immune system attack, a new study shows. The study results revolve around the immune system, the cells and proteins that destroy invading bacteria and viruses. Activating it brings about inflammation, responses like swelling and pain that result from […]

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News

First-line treatment with infliximab versus conventional treatment

Posted: January 31 2021

Abstract Objective In newly diagnosed paediatric patients with moderate-to-severe Crohn’s disease (CD), infliximab (IFX) is initiated once exclusive enteral nutrition (EEN), corticosteroid and immunomodulator therapies have failed. We aimed to investigate whether starting first-line IFX (FL-IFX) is more effective to achieve and maintain remission than conventional treatment. Design In this multicentre open-label randomised controlled trial, untreated patients […]

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Research

Early assessment with gastrointestinal ultrasound in patients hospitalised for a flare of ulcerative colitis

Predicting the need for salvage therapy: a pilot study

Approximately 30% of patients hospitalised with severe ulcerative colitis do not respond to corticosteroids, but the decision to introduce salvage therapy is delayed to at least the third day of treatment, according to the widely applied Oxford criteria to assess response. This pilot study aimed to determine if gastrointestinal ultrasound performed on admission can predict […]

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News

Potential preventative treatment demonstrated for Crohn’s disease

Posted: December 22 2020

By Jeff Hansen This research, led by University of Alabama at Birmingham researcher Charles O. Elson, M.D., professor of medicine, focused on a subset of T cells known as T memory, or Tm cells. The UAB researchers used a triple-punch treatment to remove Tm cells and increase the number of T regulatory, or Treg, cells. Both of these results were […]

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News

Gut research identifies key cellular changes associated with childhood-onset Crohn’s Disease

Posted: December 14 2020

The results are an important step towards better management and treatment of this devastating condition.  The research from the University of Cambridge and the Wellcome Sanger Institute is part of the global Human Cell Atlas initiative to map every cell type in the human body. The findings reveal intricate cellular mechanisms of how the gut […]

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Research

A large proportion of IBD patients may experience a form of PTSD

Inflammatory bowel disease patients were surveyed about their remission or flare-up status, as well as their expectations for a flare-up over the next 2 months.

About a third of inflammatory bowel disease (IBD) patients surveyed were found to meet the clinical threshold to warrant a further diagnosis of post-traumatic stress disorder (PTSD). Alexandra F. Vanderwerff, PhD, Counseling Psychology, University of Memphis, conducted a study examining the prevalence of PTSD symptoms among IBD patients. She explained to HCPLive® that her initial hypothesis centered […]

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