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Crohn’s disease in Australia – the latest research
Research Scientist and Paediatric Gastroenterologist Dr Ed Giles and Associate Professor Rebecca Lim are both leading research into Crohn’s at Hudson Institute. Dr Ed Giles is leading two Crohn’s studies at Hudson Institute. One is investigating the relationship between the microbiome and Crohn’s. The other is examining our immune system response and its relationship to inflammation […]
Research
Greenspace exposure during childhood reduces risk for IBD
By Monica Stonehill “Intervention studies designed to target specific environmental risk factors to reduce the risk of IBD should include greenspace in study design,” Michael Elten, MSc, from the School of Epidemiology and Public Health, University of Ottawa in Canada, and colleagues wrote. “It is possible that by changing our immediate environment, we could prevent childhood-onset IBD.” Elten and colleagues […]
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Surgery to heal inflamed gut may create new target for disease
A surgical procedure meant to counter ulcerative colitis, an immune disease affecting the colon, may trigger a second immune system attack, a new study shows. The study results revolve around the immune system, the cells and proteins that destroy invading bacteria and viruses. Activating it brings about inflammation, responses like swelling and pain that result from […]
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First-line treatment with infliximab versus conventional treatment
Abstract Objective In newly diagnosed paediatric patients with moderate-to-severe Crohn’s disease (CD), infliximab (IFX) is initiated once exclusive enteral nutrition (EEN), corticosteroid and immunomodulator therapies have failed. We aimed to investigate whether starting first-line IFX (FL-IFX) is more effective to achieve and maintain remission than conventional treatment. Design In this multicentre open-label randomised controlled trial, untreated patients […]
Research
Early assessment with gastrointestinal ultrasound in patients hospitalised for a flare of ulcerative colitis
Approximately 30% of patients hospitalised with severe ulcerative colitis do not respond to corticosteroids, but the decision to introduce salvage therapy is delayed to at least the third day of treatment, according to the widely applied Oxford criteria to assess response. This pilot study aimed to determine if gastrointestinal ultrasound performed on admission can predict […]
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Potential preventative treatment demonstrated for Crohn’s disease
By Jeff Hansen This research, led by University of Alabama at Birmingham researcher Charles O. Elson, M.D., professor of medicine, focused on a subset of T cells known as T memory, or Tm cells. The UAB researchers used a triple-punch treatment to remove Tm cells and increase the number of T regulatory, or Treg, cells. Both of these results were […]
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Gut research identifies key cellular changes associated with childhood-onset Crohn’s Disease
The results are an important step towards better management and treatment of this devastating condition. The research from the University of Cambridge and the Wellcome Sanger Institute is part of the global Human Cell Atlas initiative to map every cell type in the human body. The findings reveal intricate cellular mechanisms of how the gut […]
Research
A large proportion of IBD patients may experience a form of PTSD
About a third of inflammatory bowel disease (IBD) patients surveyed were found to meet the clinical threshold to warrant a further diagnosis of post-traumatic stress disorder (PTSD). Alexandra F. Vanderwerff, PhD, Counseling Psychology, University of Memphis, conducted a study examining the prevalence of PTSD symptoms among IBD patients. She explained to HCPLive® that her initial hypothesis centered […]
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Helmsley awards $4.7 million for Crohn’s diet therapy research
“Previous studies strongly suggest that dietary interventions may be beneficial in Crohn’s disease, but clear evidence-based recommendations are lacking,” Paul Scholl, program director of the Helmsley Charitable Trust Crohn’s disease program, said in the release. “By directly evaluating the effects of specific dietary regimens in preventing and treating Crohn’s disease, these new studies will provide much needed […]
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Genetic risk for fatal blood clots identified in IBD patients
In a retrospective study recently published in the journal Gastroenterology, Cedars-Sinai investigators found that a combination of rare and common genetic variants in some IBD patients significantly increased their risk of developing clot-causing thromboembolic diseases. “The genetic signature we identified more than doubled the risk of developing potentially fatal blood clots in approximately 1 in 7 IBD patients,” […]
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