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Diet–microbiota interactions in inflammatory bowel disease

Accumulating evidence suggests that the gut microbiota plays pivotal roles in the regulation of intestinal homeostasis and IBD pathogenesis.

By Kohei Sugihara and Nobuhiko Kamada  Inflammatory bowel disease (IBD), which includes ulcerative colitis (UC) and Crohn’s disease (CD), is a chronic and relapsing inflammatory disorder of the gastrointestinal tract. The prevalence of IBD has been increasing worldwide, affecting about 3 million people in the United States and 2.5 million people in Europe. Although the precise etiology […]

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News

Advancing research of inflammatory intestinal diseases

Posted: May 10 2021

By Anna MacDonald To help advance research of inflammatory intestinal diseases, Emulate recently launched the Colon Intestine-Chip, a comprehensive model that incorporates human colonic organoids and supportive colonic endothelial cells. We spoke to Dr Lorna Ewart, Emulate’s executive vice president of science, to learn more about the limitations of traditional inflammatory intestinal disease models, what makes the […]

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News

How diet influences gut bacteria and inflammation

Posted: May 4 2021

By Robby Berman According to the authors of the new study, the gut microbiome influences the balance of pro- and anti-inflammatory responses in our digestive system and throughout our immune system. When an imbalance occurs, it might influence a diverse range of inflammatory-mediated conditions, such as: heart disease inflammatory bowel disease systemic lupus erythematosus rheumatoid arthritis Certain bacteria are […]

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News

Microbial infection impairs healing in Crohn’s disease

Posted: April 30 2021

The work was led by Dr Thaddeus Stappenbeck, Chair of the Cleveland Clinic Lerner Research Institute’s Department of Inflammation & Immunity, and also included researchers from Washington University in St. Louis, Cedars-Sinai Medical Center and Dartmouth College. Together, they found that levels of the yeast Debaryomyces hansenii — commonly found in cheese and processed meat — are higher in Crohn’s disease patients, particularly abundant […]

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Research

Wisdom, loneliness and your intestinal multitude

It may take guts — or more precisely, a diverse gut microbiome — to achieve wisdom and fend off loneliness. Or perhaps it’s the other way around, report UC San Diego researchers.

 By Scott LaFee. The evolving science of wisdom rests on the idea that wisdom’s defined traits correspond to distinct regions of the brain, and that greater wisdom translates into greater happiness and life satisfaction while being less wise results in opposite, negative consequences. Scientists have found in multiple studies that persons deemed to be wiser are less prone […]

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News

Crohn’s disease may develop from warped immune cell signalling during bile acid exposure

Posted: April 13 2021

People with Crohn’s disease are typically treated with powerful anti-inflammatory medications that act throughout their body, not just in their digestive tract, creating the potential for unintended, and often serious, side effects. New research from the lab of Mark Sundrud, PhD, at Scripps Research, Florida suggests a more targeted treatment approach is possible. Crohn’s disease develops […]

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Research

The gut microbiota and inflammation: An overview

The understanding of the symbiotic relationship between the human gut bacteria and the overall functioning of the body has significantly deepened and broadened, with acceleration in research output concerning this area.

Abstract The gut microbiota encompasses a diverse community of bacteria that carry out various functions influencing the overall health of the host. These comprise nutrient metabolism, immune system regulation and natural defence against infection. The presence of certain bacteria is associated with inflammatory molecules that may bring about inflammation in various body tissues. Inflammation underlies […]

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Research

Towards a toolbox for à la carte editing of the human microbiome

Insights from bacteria-infecting viruses could vastly improve genome editing in diverse microbes, including those of the human microbiome.

By Gabriel Filsinger and Benjamin Boettner The number of bacterial cells inside each person is approximately equal to the number of human cells in the body. Interestingly, how these bacteria contribute to our health or to disease is still largely a mystery. Research on the human microbiome, the bacterial collective inhabiting our gut and other […]

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Blog

How the western diet is wreaking havoc on our guts

Posted: March 11 2021

By Markham Heid. GI researchers say that the rise of IBD and other gut disorders likely stems from a mix of factors. But, to a person, they agree that the much-maligned “Western diet” likely plays a starring role. “As soon as a country is westernized, IBD starts increasing, and I think diet is absolutely contributing […]

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News

Podcast: Faecal microbiota transplantation: indications, evidence and safety

Posted: March 4 2021

Read the full article in Australian Prescriber. Listen to podcast here. Transcript Welcome to Australian Prescriber Podcast. Australian Prescriber, independent, peer-reviewed, and free. Faecal microbiota transplantation or FMT. At first, it evoked surprise and mirth among some, but that was quickly replaced by the excitement about the possibilities that FMT might bring. It suddenly escalated as a potential […]

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