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A T-cell stimulatory protein and interleukin-10 synergize to prevent gut inflammation

Researchers have found an unexpected synergy between a T-cell stimulatory protein — the ICOS ligand — and interleukin-10, an immunoregulatory cytokine, to prevent inflammatory bowel disease in mice.

The study will aid the understanding of, and future research into, this immune disorder, which includes Crohn’s disease and ulcerative colitis. Interleukin-10, or IL-10, was already known as a major player to prevent gut inflammation by establishing and maintaining immune homeostasis in the gut, where it is vital for the host to have a peaceful […]

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