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Advancing research of inflammatory intestinal diseases

Posted: May 10 2021

By Anna MacDonald To help advance research of inflammatory intestinal diseases, Emulate recently launched the Colon Intestine-Chip, a comprehensive model that incorporates human colonic organoids and supportive colonic endothelial cells. We spoke to Dr Lorna Ewart, Emulate’s executive vice president of science, to learn more about the limitations of traditional inflammatory intestinal disease models, what makes the […]

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Blog

What to eat to help reduce colon inflammation

Posted: April 28 2021

Medically reviewed by Sade Meeks, MS, RD — Written by Jenna Fletcher  During a Flare It is advisable for people with IBD to take the following measures with regard to their diet during a flare-up: Eat less fiber A person should choose white breads and rice over whole grain. Foods with less than 2 grams of fiber per serving are most suitable. Vegetables A person […]

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Research

Probiotic Lactobacillus acidophilus shows promise for treating inflammatory bowel disease and other intestinal inflammation disorders

Probiotic strain LA1 has a therapeutic effect that both prevents and treats intestinal inflammatory disorders caused by “leaky gut,” report researchers in The American Journal of Pathology.

Intestinal epithelial tight junctions (TJs) act as a functional and structural barrier against harmful antigens that promote intestinal inflammation in inflammatory bowel disease (IBD) and other inflammatory conditions of the gut. A defective intestinal TJ barrier, sometimes known as “leaky gut,” plays an important role in exacerbating and prolonging intestinal inflammation. New research reported in The American Journal […]

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Research

Wisdom, loneliness and your intestinal multitude

It may take guts — or more precisely, a diverse gut microbiome — to achieve wisdom and fend off loneliness. Or perhaps it’s the other way around, report UC San Diego researchers.

 By Scott LaFee. The evolving science of wisdom rests on the idea that wisdom’s defined traits correspond to distinct regions of the brain, and that greater wisdom translates into greater happiness and life satisfaction while being less wise results in opposite, negative consequences. Scientists have found in multiple studies that persons deemed to be wiser are less prone […]

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Research

Defects in a specific cell type may cause ulcerative colitis

There are many variants of "goblet cells" in the intestines and they seem to have different functions, according to a new study from the University of Gothenburg.

The entire inside of our intestines is covered by a thin layer of mucus that protects the fragile mucous membrane (mucosa) from bacteria and other microorganisms. If the microorganisms repeatedly come into contact with the intestinal mucosa, inflammation and even cell changes may result. These increase the risk of intestinal cancer. In a healthy colon, […]

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News

Crohn’s disease may develop from warped immune cell signalling during bile acid exposure

Posted: April 13 2021

People with Crohn’s disease are typically treated with powerful anti-inflammatory medications that act throughout their body, not just in their digestive tract, creating the potential for unintended, and often serious, side effects. New research from the lab of Mark Sundrud, PhD, at Scripps Research, Florida suggests a more targeted treatment approach is possible. Crohn’s disease develops […]

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Research

The gut microbiota and inflammation: An overview

The understanding of the symbiotic relationship between the human gut bacteria and the overall functioning of the body has significantly deepened and broadened, with acceleration in research output concerning this area.

Abstract The gut microbiota encompasses a diverse community of bacteria that carry out various functions influencing the overall health of the host. These comprise nutrient metabolism, immune system regulation and natural defence against infection. The presence of certain bacteria is associated with inflammatory molecules that may bring about inflammation in various body tissues. Inflammation underlies […]

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News

For good health, trust your gut

Posted: March 23 2021

By Michael Miller University of Cincinnati assistant professor Ashley Ross says your body is full of neurons that regulate digestion, inflammation and a host of other biological processes. In her chemistry lab in UC’s College of Arts and Sciences, she is studying the role they play in the immune system. “I’m fascinated by the concept that […]

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News

RCSI researchers discover new way to halt excessive inflammation

Posted: March 15 2021

The discovery has the potential to protect the body from unchecked damage caused by inflammatory diseases. The paper, authored by RCSI researchers, is published in Opens in new windowNature Communications. When immune cells (white blood cells) in our body called macrophages are exposed to potent infectious agents, powerful inflammatory proteins known as cytokines are produced to […]

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Blog

Natural remedies for inflammation

Posted: March 9 2021

Written by Zawn Villines. What is inflammation? Inflammation is part of the body’s natural response to illness. It causes blood vessels to dilate, which allows more white and red blood cells to reach areas of the body that are damaged. In the short term, inflammation is helpful. Acute inflammation helps the body heal from things such […]

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