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A T-cell stimulatory protein and interleukin-10 synergize to prevent gut inflammation

Researchers have found an unexpected synergy between a T-cell stimulatory protein — the ICOS ligand — and interleukin-10, an immunoregulatory cytokine, to prevent inflammatory bowel disease in mice.

The study will aid the understanding of, and future research into, this immune disorder, which includes Crohn’s disease and ulcerative colitis. Interleukin-10, or IL-10, was already known as a major player to prevent gut inflammation by establishing and maintaining immune homeostasis in the gut, where it is vital for the host to have a peaceful […]

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Study reveals genetic and cellular mechanisms of Crohn’s disease

Posted: April 14 2021

Mount Sinai researchers have identified genetic and cellular mechanisms of Crohn’s disease, providing new insights for future treatments that could offer a tailored approach to patients with the chronic inflammatory disease, according to a study published in Nature on March 31. The researchers found that blocking the common cytokine receptor subunit gp130 may benefit some patients with […]

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