Possible targets to help tackle Crohn’s disease
An abnormal reaction of the immune system to certain bacteria in the intestines has had new light shed on it.
The research has focused on different types of cells called macrophages, which are part of our immune system and are found in most tissues, where they patrol for potential harmful organisms and destroy them.
In inflammatory diseases, like Crohn’s, macrophages mediate the inflammatory destruction of the gut. Just how the tissue reacts (inflammation or suppression) is dependent on the type of macrophage cell present, and how it is stimulated — and scientists have been trying to get to the bottom of this.
The new research has shown how different types of macrophage — one type being pro-inflammatory and the other being anti-inflammatory — exhibit quite different molecular mechanisms involved in switching off their functional behaviour when bacteria are present.
And this difference, as study author Dr Andrew Foey explains, highlights the possibility of targeting and selectively suppressing the pro-inflammatory cells that drive diseases such as Crohn’s disease.
Read full article at https://www.sciencedaily.com/releases/2019/06/190617125131.htm