Poo Transplant Effective Treatment For Chronic Bowel Condition
A short duration of low intensity FMT induced remission in ulcerative colitis, with a 32% rate of remission.
Poo transplant or “Faecal microbiota transplantation” (FMT) can successfully treat patients with ulcerative colitis, new research from the University of Adelaide shows.
Researchers found a short duration of low intensity FMT using anaerobically (in an oxygen-free environment) prepared pooled donor FMT could induce remission in ulcerative colitis, with a 32% rate of remission compared to 9% with placebo. This is a similar treatment result to the best currently available therapies.
Many of the currently available therapies for ulcerative colitis improve the disease by suppressing the immune system which can lead to potential side effects like infection or malignancy.
An agreement has already been reached with UK company Microbiotica to commercialise the development of a microbial therapeutic from the study.
“Our long-term aim is to develop rationally designed microbial therapies that can replace FMT,’’ says Dr Costello.
“These will have bacteria in a pill that can carry out the therapeutic effect without the need to take whole faeces.
Further studies will investigate whether FMT can maintain remission in ulcerative colitis.