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People with inflammatory bowel disease might be at higher risk for dementia, study finds

It appears that gut imbalances associated with IBD may impact cognitive decline.

According to the researchers, their study was the first to explore IBD as a factor for dementia.


“It’s been quite a few years that we’ve known IBD is associated with depression and anxiety,” said Dr. Bing Zhang, a fellow in the gastroenterology division of the department of medicine at the University of California, San Francisco, and coauthor of the new study that published Tuesday in the journal Gut.


“In fact, we knew 30% of people with IBD would develop these,” Zhang said. “However, it wasn’t until recently that we started looking at more neurocognitive changes and neurocognitive decline.”


Our gut bacteria, or microbiome, is composed of bacteria, viruses and microbes that are tiny but actually quite mighty — they appear to aid our metabolic functions, help protect us from pathogens and manage our immune systems.


IBD is thought to originate from a dysfunctional or heightened immune response to changes in the microbiome of a person who is genetically susceptible. It could also be triggered by environmental factors.


The study analyzed 1,742 patients with IBD who were 45 or older, culled from the Taiwanese National Health Insurance Research Database,and compared them to more than 17,400 people without the disease.


They were tracked for up to 16 years to examine the relationship between dementia and IBD.The study was observational and didn’t establish cause and effect. It also didn’t look at lifestyle factors such as diet and exercise.


Participants with IBD had a 4.1% higher incidence of dementia, and were diagnosed more than seven years earlier than those patients without IBD. The overall incidence of dementia was 5.5% among IBD patients compared to 1.4% among those who didn’t have IBD.


Individuals with IBD were at greatest risk for two types of dementia: Alzheimer’s dementia, which is caused by damage and death to nerve cells and affects memory, thinking and behavior; and vascular dementia, which stems from conditions that block or reduce blood flow to the brain.


The study found the association between IBD and dementia was the same for men and women. There was no difference in riskbetween those with ulcerative colitis or Crohn’s disease, but there was an increased risk for dementia as the severity and duration of IBD rose.


According to prior studies, patients with IBD who are in remission and not experiencing symptoms can still have remaining inflammation. Because of those previous findings, the authors think both inflammation during symptoms and inflammation during periods of remission could contribute to development of dementia.


Read full People with inflammatory bowel disease might be at higher risk for dementia, study finds by Kristen Rogers.


Posted on: June 25 2020

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