Mechanisms by which Stress Affects the Experimental and Clinical Inflammatory Bowel Disease (IBD): Role of Brain-Gut Axis
By Brzozowski, Bartosz; Mazur-Bialy, Agnieszka
Researchers have conducted a study to investigate the effect of stress on inflammatory bowel disease, which has seen to alter a so called “braingut axis”; reflecting changes in cortrophin releasing hormone, mast cells activity, neurotransmission at the atomic nerves system and intestinal barrier function. The appearance of chronic stress has been linked to the increase in permeability of the intestinal wall, leading to an increase in bacterial translocation. This increased prevalence in bacteria in the colonic tissue in addition to a suppressed immune system can lead to a negative impact on IBD.