Crohn’s disease in Australia – the latest research
Treatments are highly personalised, complex and often aimed at reducing inflammation.
Research Scientist and Paediatric Gastroenterologist Dr Ed Giles and Associate Professor Rebecca Lim are both leading research into Crohn’s at Hudson Institute.
Dr Ed Giles is leading two Crohn’s studies at Hudson Institute. One is investigating the relationship between the microbiome and Crohn’s. The other is examining our immune system response and its relationship to inflammation in the gastrointestinal tract.
“Children diagnosed with IBD have a three times higher mortality rate than the general public before the age of 40. We need to work harder to understand the cause of IBD to develop safer and more effective treatments” – Dr Ed Giles
A/Prof Rebecca Lim’s team is currently conducting a clinical trial testing the use of stem cells (therapeutic amniotic stem cells, from the amniotic sac) to treat patients with fistulae (leaks or abscesses that form in the bowel wall) arising from Crohn’s. This trial recruited patients who did not respond to at least one type of conventional therapy.
“There really aren’t good treatment options for the serious cases. There’s surgery and then there’s living with it – which impacts quality of life, ability to work and sexual dysfunction” – A/Prof Rebecca Lim
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