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Genetic risk for fatal blood clots identified in IBD patients

Posted: November 11 2020

In a retrospective study recently published in the journal Gastroenterology, Cedars-Sinai investigators found that a combination of rare and common genetic variants in some IBD patients significantly increased their risk of developing clot-causing thromboembolic diseases. “The genetic signature we identified more than doubled the risk of developing potentially fatal blood clots in approximately 1 in 7 IBD patients,” […]

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Severe form of inflammatory bowel disease linked to mouth bacteria

Posted: November 9 2020

Severe ulcerative colitis – a form of inflammatory bowel disease (IBD) – has been linked to a newly-discovered strain of oral bacteria, a study led by UNSW Sydney has found. Scientists have discovered a molecule called ‘pSma1’ in bacterial cell samples from people with severe ulcerative colitis. The molecule was found in some strains of […]

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Early, tight control of Crohn’s disease may have lasting benefits

Posted: October 26 2020

Early approaches to treatment of Crohn’s disease followed a step-up algorithm in which the newer medications would only be used if the patient did not benefit from established therapies. This sequential approach — termed step therapy — has more recently been called into question, as studies have repeatedly shown that the newer drugs for Crohn’s […]

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Cure found for rare form of inflammatory bowel disease

Posted: October 18 2020

The disease, called G6PC3 deficiency, affects around one in a million people and causes inflammation of the bowel, as well as lung infections. The team also showed that in affected patients, white blood cells called neutrophils trigger inflammation when exposed to gut bacteria, despite treatment with commonly available biological therapies. The patients were treated at the Royal […]

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Team develops wearable sensor to help those with inflammatory bowel disease

Posted: October 12 2020

University of Texas at Dallas researchers have designed a wearable device that monitors sweat for biomarkers that could signal flare-ups of inflammatory bowel disease (IBD). A team of bioengineers demonstrated the wristwatch-like device in a proof-of-concept study funded by the Crohn’s & Colitis Foundation and published online July 28 and in the October print edition […]

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Prevalence of irritable bowel syndrome-type symptoms in patients with inflammatory bowel disease in remission

A systematic review and meta-analysis

Summary Background Patients with inflammatory bowel disease (IBD) often report symptoms compatible with irritable bowel syndrome (IBS), which might have an effect on psychological health. However, previous estimates of the magnitude of this issue have not accounted for ongoing inflammation as the potential cause. We updated a previous systematic review and meta-analysis to determine prevalence […]

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The association between inflammatory potential of diet and disease activity

Results from a cross-sectional study in patients with inflammatory bowel disease

Abstract Background Diet may play a role in disease status in patients with inflammatory bowel disease. We tested whether the inflammatory potential of diet, based on a summation of pro- and anti-inflammatory nutrients, is associated with disease activity in patients with Crohn’s disease and ulcerative colitis. Methods Participants completed a disease activity questionnaire (short Crohn’s […]

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Cell therapy designed to treat inflammatory bowel disease

The research by the UPV/EHU-University of the Basque Country, in collaboration with Harvard University, has yielded highly encouraging results, and studies in animal models have already begun

The UPV/EHU’s NanoBioCel research group has for many years been developing systems enabling cells to be used as drugs. Cell therapy raises hopes for treating those diseases for which there are as yet no effective pharmacological solutions. Biomaterials, a leading journal in the field of materials sciences and medicine, has just published the paper ‘Multifunctional […]

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Blueberry compound may provide new inflammatory bowel disease therapy

Posted: October 5 2020

They believe it can provide a potential therapeutic option for chronic inflammatory diseases, including inflammatory bowel disease (IBD). The team, led by Chiharu Nishiyama, PhD, published its study “Pterostilbene reduces colonic inflammation by suppressing dendritic cell activation and promoting regulatory T cell development” in The FASEB Journal. The compound is similar to another phytocompound known to […]

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COVID-19 vaccinations in patients with inflammatory bowel disease

The COVID-19 pandemic has led to substantial concerns for patients with IBD who are on immunosuppressive medications, many of whom are using additional protective measures.

Advances in the treatment of patients with inflammatory bowel disease (IBD) have substantially improved disease activity and quality of life, and reduced hospitalisation rates and the need for surgery. However, prolonged immunosuppression in these patients can result in increased susceptibility to opportunistic infections. Many of these infections are preventable through vaccination and immunisation strategies that […]

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