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Research

Glial cells crucial to maintaining healthy gut immunity

Researchers at the Francis Crick Institute have uncovered a fundamental role of glial cells in the nervous system of the gut in maintaining a healthy intestine.

These cells have been found to coordinate the immune responses of the gut following pathogen invasion and could be key targets when exploring new treatments for inflammatory bowel conditions. Maintaining a healthy intestine and repairing tissue after infection or other types of injury is a complex process, and if this goes wrong, it can lead […]

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National health literacy programme for people living with IBD

The aim of the CCA IBD project is to implement the Optimising Health Literacy and Access (Ophelia) process over 3 years to collaboratively codesign ways to improve delivery of information, services and resources for people with IBD and their carers.

Authors: Melanie Hawkins, Wayne Massuger, Christina Cheng, Roy Batterham, Gregory T Moore, Simon Knowles, Ranjit G Nadarajah, Leanne Raven, Richard H Osborne Introduction Non-government organisations (NGOs) represent the interests of the communities they serve, whether this be locally, nationally or internationally.1 The role of a community sector NGO is to give voice to its community through […]

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Study shows diet has ‘underappreciated role’ in treating ulcerative colitis

Patients with ulcerative colitis following a novel diet achieved higher clinical remission and mucosal healing compared with patients who received a single donor fecal transplantation, with or without diet, according to a study.

By Monica Stonehill “We evaluated whether integration of novel diets for donors and patients in addition to fecal transplantation (FT) could increase FT remission rate in refractory UC,” Chen Sarbagili Shabat, of the pediatric gastroenterology unit at Wolfson Medical Center’s PIBD Research Center in Holon, Israel, and colleagues wrote. “UCED alone appeared to achieve higher clinical remission and mucosal healing than […]

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New treatment for inflammatory bowel disease: opioids may cure that “bad gut feeling”

Posted: October 7 2021

Opioid receptors play key roles in regulating our senses and emotions. Recently, their discovery outside the nervous system raised several questions about the effects of opioids on the immune system. Now, researchers from Japan have shown that KNT-127—a drug that targets delta opioid receptors—can reduce pro-inflammatory signals in the colon. Their research highlights the immunomodulatory […]

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Unique imaging technology to map cells tied to inflammatory bowel disease

Posted: September 24 2021

New “maps” of hundreds of thousands of cells related to inflammatory bowel disease shed greater light on their effects on intestinal tissues through a newly utilized imaging technique called “imaging mass cytometry.” The novel findings by researchers at the Perelman School of Medicine at the University of Pennsylvania provide a possible path to better targeted […]

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Novel mechanism links genetic defect in IBD patients to gut leakiness

UC Riverside-led study in mice and human tissue is the first to show how a disease mutation weakens barrier properties of epithelial cells lining the gut

By Iqbal Pittalwala A team of researchers led by a biomedical scientist at the University of California, Riverside, has identified a novel mechanism by which loss-of-function mutations in the gene PTPN2, found in many patients with inflammatory bowel disease, or IBD, affect how intestinal epithelial cells maintain a barrier. The intestinal epithelium, a single layer […]

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Precursor to ulcerative colitis in healthy individuals years before onset of disease

Posted: September 10 2021

By Maria Elisson Ulcerative colitis is an inflammatory bowel disease (IBD), with symptoms normally setting in between late adolescence and the age of 30. What causes it is not yet known, but there is lots to suggest that the disease is a result of an interplay between genetic and environmental factors and that gut flora […]

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High burden of ulcerative colitis in Australia

Both patients and physicians request more time for routine ulcerative colitis appointments.

By Kenny Walter While the majority of patients are satisfied with ulcerative colitis (UC) treatments, the overall disease burden remains high in Australia. A team, led by Susan J. Connor, PhD, Department of Gastroenterology, Liverpool Hospital, South Western Sydney Clinical School, University of New South Wales, Ingham Institute of Applied Medical Research, evaluated the impact , perceptions […]

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People with IBD often have inadequate diets

IBD patients were less likely to have diets that regularly include vegetables, cereals, breads, and diary.

By Kenny Walter It has been long known that diet decisions can increase the risk of developing inflammatory bowel disease (IBD), but new research shows poor diet might also be common among patients diagnosed with the disease. A team, led by Kelly Lambert, School of Medicine, Faculty of Science, Medicine and Health, Illawarra Health and Medical Research […]

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Genetic mutation linked to rare inflammatory bowel disease

Posted: August 10 2021

Scientists from Johns Hopkins Medicine, in collaboration with national and international researchers, have identified a genetic mutation in a small number of children with a rare type of inflammatory bowel disease. They say that this discovery could help to define the cause of more common bowel diseases and lead to more targeted treatments for gut conditions. The study has been […]

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