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Diet–microbiota interactions in inflammatory bowel disease

Accumulating evidence suggests that the gut microbiota plays pivotal roles in the regulation of intestinal homeostasis and IBD pathogenesis.

By Kohei Sugihara and Nobuhiko Kamada  Inflammatory bowel disease (IBD), which includes ulcerative colitis (UC) and Crohn’s disease (CD), is a chronic and relapsing inflammatory disorder of the gastrointestinal tract. The prevalence of IBD has been increasing worldwide, affecting about 3 million people in the United States and 2.5 million people in Europe. Although the precise etiology […]

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Advancing research of inflammatory intestinal diseases

Posted: May 10 2021

By Anna MacDonald To help advance research of inflammatory intestinal diseases, Emulate recently launched the Colon Intestine-Chip, a comprehensive model that incorporates human colonic organoids and supportive colonic endothelial cells. We spoke to Dr Lorna Ewart, Emulate’s executive vice president of science, to learn more about the limitations of traditional inflammatory intestinal disease models, what makes the […]

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How diet influences gut bacteria and inflammation

Posted: May 4 2021

By Robby Berman According to the authors of the new study, the gut microbiome influences the balance of pro- and anti-inflammatory responses in our digestive system and throughout our immune system. When an imbalance occurs, it might influence a diverse range of inflammatory-mediated conditions, such as: heart disease inflammatory bowel disease systemic lupus erythematosus rheumatoid arthritis Certain bacteria are […]

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Podcast: Perivascular nerve dysfunction in inflammatory bowel disease

What is the effect of vascular function in the pathogenesis of Inflammatory Bowel Disease (IBD)?

Find podcast here. IBD patients are at greater risk for developing cardiovascular disease compared to age-matched peers. Listen as Consulting Editor Camilla Wenceslau (University of Toledo) interviews senior author Erika Boerman (University of Missouri) and expert Pooneh Bagher (Texas A&M Health Science Center) about this novel study by Norton et al. Decreased blood flow to […]

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Patients’ experiences and challenges in living with inflammatory bowel Disease

The purpose of this study was to explore patient experiences in living with IBD and uncover factors that contribute to psychological distress.

Purpose Inflammatory bowel disease (IBD) significantly impacts patients’ quality of life and imposes a considerable psychological, social, and financial burden. While the relationship between disease activity and quality of life is well established, the subjective challenges of living with IBD are more difficult to assess, and suggestions for improving patient experiences are lacking. The aim […]

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The arthritis connection to inflammatory bowel disease (IBD): why has it taken so long to understand it?

Inflammatory bowel disease (IBD) associated arthritis is a subgroup of spondyloarthritis (SpA) that has suffered from lack of recognition in rheumatology clinical and research circles for over 100 years.

Introduction The initial description of a potential cause and effect relationship between arthritis and inflammatory bowel disease (IBD) likely goes back to well over 100 years ago in 1895 where William H White wrote, ‘among twenty-three cases of ulcerative colitis… two had urate of soda in their joints’.1 Almost 30 years later and into the next […]

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Microbial infection impairs healing in Crohn’s disease

Posted: April 30 2021

The work was led by Dr Thaddeus Stappenbeck, Chair of the Cleveland Clinic Lerner Research Institute’s Department of Inflammation & Immunity, and also included researchers from Washington University in St. Louis, Cedars-Sinai Medical Center and Dartmouth College. Together, they found that levels of the yeast Debaryomyces hansenii — commonly found in cheese and processed meat — are higher in Crohn’s disease patients, particularly abundant […]

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Sarcopenia and vitamin D deficiency in patients with Crohn’s disease: Pathological conditions that should be linked together

Sarcopenia is a prevalent condition in patients with Crohn’s disease (CD), representing an independent predictor factor for the development of major postoperative complications.

Excerpt: Introduction Crohn’s disease (CD) is a chronic and progressive inflammatory bowel disease (IBD) that has a high impact on a patient’s quality of life. It is well known that all segments of the gastrointestinal tract can be affected by CD, mainly the terminal ileum and colon. Inflammation is generally segmental, asymmetrical, and transmural. Although […]

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Probiotic Lactobacillus acidophilus shows promise for treating inflammatory bowel disease and other intestinal inflammation disorders

Probiotic strain LA1 has a therapeutic effect that both prevents and treats intestinal inflammatory disorders caused by “leaky gut,” report researchers in The American Journal of Pathology.

Intestinal epithelial tight junctions (TJs) act as a functional and structural barrier against harmful antigens that promote intestinal inflammation in inflammatory bowel disease (IBD) and other inflammatory conditions of the gut. A defective intestinal TJ barrier, sometimes known as “leaky gut,” plays an important role in exacerbating and prolonging intestinal inflammation. New research reported in The American Journal […]

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Wisdom, loneliness and your intestinal multitude

It may take guts — or more precisely, a diverse gut microbiome — to achieve wisdom and fend off loneliness. Or perhaps it’s the other way around, report UC San Diego researchers.

 By Scott LaFee. The evolving science of wisdom rests on the idea that wisdom’s defined traits correspond to distinct regions of the brain, and that greater wisdom translates into greater happiness and life satisfaction while being less wise results in opposite, negative consequences. Scientists have found in multiple studies that persons deemed to be wiser are less prone […]

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