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Australian Inflammatory Bowel Disease Microbiome Study

A longitudinal cohort study with clinical data, patient-reported outcomes data, and biological samples collected from participants over a 24-month period.

The microbiome and links to IBD Inflammatory bowel disease (IBD), comprising the 2 main forms – Crohn’s disease and ulcerative colitis, is a global disease challenge. It affects approximately 1 in 250 Australians, with over 80,000 Australians currently living with IBD. IBD arises from a dysregulated immune response to alterations in the gut microbiota in […]

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Rare immune cells drive gut repair

But can tip toward cancer or fibrosis in inflammatory bowel disease.

A team of scientists, led by King’s College London, have discovered an unexpected tissue reparative role for a rare immune cell type in the gut that could tip toward fibrosis or cancer if abnormal or impaired. The breakthrough, revealed in a paper published in Nature Materials, will have important implications for treating patients who suffer from […]

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The psychosocial burden of inflammatory bowel disease in adolescents and young adults

This study examined the psychosocial burden of inflammatory bowel disease (IBD) in young people aged 15‐25 years attending a tertiary specialist health centre for adolescents and young adults in Brisbane.

Methods Young people with IBD provided demographic information and psychosocial data via a cross‐sectional self‐report survey. Psychosocial data included the Kessler Psychological Distress Scale (K‐10), Perceived Stress Scale (PSS‐10), Brief Illness Perception Questionnaire (Brief IPQ), World Health Organisation Wellbeing Index (WHO‐5), Pediatric Quality of Life Inventory (PedsQL), Short Quality of Life Questionnaire for IBD (SIBDQ), […]

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Immune cells sculpt circuits in the brain

Brain immune cells, called microglia, protect the brain from infection and inflammation. It turns out that they also sculpt circuits in the developing brain in response to sensory cues.

Immune cells play an unexpected role in fine-tuning the brain’s neural circuits, according to research published in September, 2020 in Neuron. The immune cells that reside there, known as microglia, not only protect the brain from infection and inflammation, they also help physically sculpt circuits in the developing brain. The new work demonstrates that microglia also […]

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News

CCA IBD PhD Scholarship

Posted: September 10 2020

This scholarship makes a provision of $25,000 per annum for up to (3) years full-time supporting CCA’s strategic priority of building inflammatory bowel disease (IBD) research capacity in Australia whilst we search for a cause or cure for IBD. The award is designed for candidates at an early stage in their careers, for example (but […]

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Inflammatory bowel disease linked to an immune cell run amok

Posted: August 31 2020

Read Inflammatory bowel disease linked to an immune cell run amok by Scott LaFee. Inflammatory bowel disease (IBD) is a group of intestinal disorders affecting an estimated six to eight million people worldwide. Although there are many treatments for IBD, a number of patients fail to respond long-term, leaving those afflicted with a host of chronic […]

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Harvard study links inflammatory diet to Crohn’s disease

Posted: August 31 2020

Read Harvard study links inflammatory diet to Crohn’s disease. A Harvard study published online May 7, 2020, by Gastroenterology found another potential risk: Crohn’s disease, a condition characterized by areas of inflammation throughout the large and small intestines. Researchers evaluated 30 years’ worth of self-reported diet information from more than 208,000 men and women. Diets were scored based […]

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Review: Probiotics for induction of remission in Crohn’s disease

Probiotics can be used to manipulate the microbiome and have therefore been considered as a potential therapy for CD.

There is some evidence that probiotics benefit other gastrointestinal conditions, such as irritable bowel syndrome and ulcerative colitis, but their efficacy in CD is unclear. This is the first update of a Cochrane Review previously published in 2008. Read the full review here.

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Researchers identify enzyme linked to colitis

Posted: August 25 2020

In a new study published in Immunity, lead author Nan Gao, Associate Professor of Cell Biology in the Department of Biological Sciences, School of Arts and Sciences-Newark, reports that in people with ulcerative colitis, the gut enzyme lysozyme which normally functions to restrain bacterial growth, instead stimulates inflammation. This results in the formation of ulcers and […]

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Impact and resistance training boosts bone strength and muscle function in those with Crohn’s disease

Posted: August 19 2020

People with Crohn’s are also more at risk of developing thinner and weaker bones – osteoporosis – due to factors such as inflammation of the gut, low levels of calcium and vitamin D, taking steroids or removal of parts of the small bowel. Reduced muscle strength in comparison to the general population is also common. […]

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