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Faecal microbiota transplantation: indications, evidence and safety
Read the full article in Australian Prescriber. Listen to podcast here. Transcript Welcome to Australian Prescriber Podcast. Australian Prescriber, independent, peer-reviewed, and free. Faecal microbiota transplantation or FMT. At first, it evoked surprise and mirth among some, but that was quickly replaced by the excitement about the possibilities that FMT might bring. It suddenly escalated as a potential […]
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Crohn’s disease in Australia – the latest research
Research Scientist and Paediatric Gastroenterologist Dr Ed Giles and Associate Professor Rebecca Lim are both leading research into Crohn’s at Hudson Institute. Dr Ed Giles is leading two Crohn’s studies at Hudson Institute. One is investigating the relationship between the microbiome and Crohn’s. The other is examining our immune system response and its relationship to inflammation […]
Research
Greenspace exposure during childhood reduces risk for IBD
By Monica Stonehill “Intervention studies designed to target specific environmental risk factors to reduce the risk of IBD should include greenspace in study design,” Michael Elten, MSc, from the School of Epidemiology and Public Health, University of Ottawa in Canada, and colleagues wrote. “It is possible that by changing our immediate environment, we could prevent childhood-onset IBD.” Elten and colleagues […]
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New potential therapy for Crohn’s disease in children
Scientists from the Stanley Manne Children’s Research Institute at Ann & Robert H. Lurie Children’s Hospital of Chicago demonstrated that a nanotherapy reduces intestinal inflammation and shrinks lesions in a rodent model of severe Crohn’s disease. This approach could become an alternative to biologic antibody therapies that carry many side effects, including increased risk of certain cancers. […]
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Fungi in the gut prime immunity against infection
Common fungi, often present in the gut, teach the immune system how to respond to their more dangerous relatives, according to new research from scientists at Weill Cornell Medicine. Breakdowns in this process can leave people susceptible to deadly fungal infections. The study, published Feb. 5 in Cell, reveals a new twist in the complex relationship […]
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Study identifies ‘Achilles heel’ of bacteria linked to Crohn’s disease
In a study published Feb. 3 in Cell Host and Microbe, the investigators showed that patients with Crohn’s disease have an overabundance of a type of gut bacteria called adherent-invasive Escherichia coli (AIEC), whichpromotes inflammation in the intestine. Their experiments revealed that a metabolite produced by the bacteria interacts with immune system cells in the lining of […]
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Scientists switch on tissue repair in inflammatory bowel disease
When functioning correctly, the immune system protects against harmful agents such as bacteria that get into the body. But in conditions such as inflammatory bowel disease (IBD), the immune system attacks the tissues that line the gut, forming ulcers and causing pain and discomfort. Nearly 3.9 million women and 3.0 million men are living with […]
Research
International perspectives on management of inflammatory bowel disease
Abstract Background Inflammatory bowel diseases (IBD), including Crohn disease (CD) and ulcerative colitis (UC), are complex disorders with multiple comorbidities. We conducted international patient and physician surveys to evaluate current experiences and perceptions of patients with CD or UC and physicians who treat IBD. Methods The IBD Global Assessment of Patient and Physician Unmet Need […]
Research
Ulcerative colitis narrative global survey findings
Abstract Background The Ulcerative Colitis (UC) Narrative is a global patient and physician survey aimed at identifying the impact of UC and comparing and contrasting perceptions of UC burden and management approaches. Methods Surveys of patients with UC (self-reported diagnosis; n = 2100) and physicians (n = 1254) were completed across 10 countries by The […]
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‘Creeping Fat’ in Crohn’s patients linked to bacteria
In many patients with Crohn’s disease abdominal fat migrates to the wall of the inflamed small intestines. What prompts the fat tissue to “creep” through the abdomen and wrap around the intestines of many patients with this inflammatory bowel disease (IBD) has been an enduring mystery. Now, investigators have identified a critical clue. In a study […]
Latest Articles
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NewsFaecal microbiota transplantation: indications, evidence and safety
Is one person’s faeces another person’s therapy? David Liew interviews Dr Sam Costello about the indications, evidence and safety of faecal microbiota transplantation. -
NewsHow to look past the chatter and manage your inner voice
It can be tough to manage your inner voice. -
NewsCrohn’s disease in Australia – the latest research
Treatments are highly personalised, complex and often aimed at reducing inflammation.
