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Common mistakes that can make ulcerative colitis worse

Posted: October 22 2019

When you experience an ulcerative colitis flare, it’s easy to assign blame, be it on last night’s spicy dinner or on that extra-large coffee. In actuality, flares are unpredictable — there are no proven triggers or foolproof ways to prevent them. The most important thing to do if you have ulcerative colitis? “Take your medications as prescribed […]

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News

Healthiest gut bacteria with plant-based or Mediterranean diet

Posted: October 21 2019

The study included four different groups of people: the population at large; people suffering from the chronic intestinal inflammatory disorder called Crohn’s disease; people with another similar gut disorder called ulcerative colitis; and people with irritable bowel syndrome (IBS). This helped them describe the individual’s microbial pattern. This was then correlated with the results of […]

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News

Crohn’s disease study identifies genetic variant with potential to personalise treatment

Posted: October 10 2019

A UK wide collaboration led by the University of Exeter, Royal Devon & Exeter NHS Foundation Trust and the Wellcome Sanger Institute, has demonstrated that a genetic variant carried by 40% of the population explains why some patients develop antibodies against the anti-TNF drugs, infliximab and adalimumab and lose response. The authors conclude that a […]

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News

Genetic data now available for bacteria central to Crohn’s disease

Posted: October 10 2019

By studying a surgically removed, damaged bowel from a patient, researchers were able to culture bacteria from a special form of microscopic lesions that they earlier discovered and that can be present within the gut wall of the inflamed bowel in Crohn’s disease. After growing the bacteria in their laboratory, they chose one representative species, and performed a complete genome sequence […]

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News

When blood vessels are overly permeable

Posted: October 9 2019

Diseases in humans are often caused by malfunctioning cells. Epithelium cells, which form the barrier between the bowel and surrounding tissue, and inflammatory cells have been the focus of investigations of the mechanisms of chronic inflammatory diseases of the bowel up to now. While it is well known that inflammatory cells can only reach the […]

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News

Scientists find timekeepers of gut’s immune system

Posted: October 9 2019

As people go through their daily and nightly routines, their digestive tracts follow a routine, too: digesting food and absorbing nutrients during waking hours, and replenishing worn-out cells during sleep. Shift work and jet lag can knock sleep schedules and digestive rhythms out of whack. Such disruptions have been linked to increased risk of intestinal […]

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News

A Small Taste of the Low FODMAP Diet

Posted: October 8 2019

About the author: Anne-Marie Stelluti is a registered dietitian in Vancouver and business owner of Modern Gut Health. She is a member of the College of Dietitians of British Columbia and has completed FODMAP training with Monash University in 2019.   What would you say most motivates you as a dietitian?    Helping others in a meaningful […]

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Research

Nanotechnology in the Treatment of Inflammatory Bowel Disease

Particles, in the size of nanometres, can be used to deliver medications directly to the area of inflammation thus avoiding drug-associated systemic side effects.

To date, there is no cure for IBD, and therapy is aimed to achieve and maintain remission from inflammatory episodes. Inflammatory bowel disease treatment currently consists of anti-inflammatory agents such as 5-aminosalicylates (5-ASAs), corticosteroids, immunosuppressants, and biologic agents such as tumor necrosis factor alpha (TNF-α) antagonists, anti-interleukins, and anti-integrins.6 These drugs can induce and maintain remission; […]

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News

Piecing together the puzzle of IBD

Posted: October 1 2019

Imagine trying to complete a jigsaw puzzle but only having half the pieces. You manage to piece together one or two sections, but many others remain a mystery, and you are never able to see the complete picture. In some ways, this is what it has been like for doctors treating inflammatory bowel diseases (IBD). […]

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News

Q&A: VARSITY, UNIFI add to the armamentarium for ulcerative colitis

Posted: October 1 2019

Two trials – the VARSITY and UNIFI trials – published in The New England Journal of Medicine on Wednesday helped to provide information about which therapies might be beneficial to patients with UC and in what circumstances. The UNIFI trial, which was previously presented at both the United European Gastroenterology Week and Digestive Disease Week, demonstrated that two […]

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