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Medication & Treatment

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Potential preventative treatment demonstrated for Crohn’s disease

Posted: December 22 2020

By Jeff Hansen This research, led by University of Alabama at Birmingham researcher Charles O. Elson, M.D., professor of medicine, focused on a subset of T cells known as T memory, or Tm cells. The UAB researchers used a triple-punch treatment to remove Tm cells and increase the number of T regulatory, or Treg, cells. Both of these results were […]

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News

Potential new target to combat inflammatory diseases

Posted: December 22 2020

WEHI’s Associate Professor Seth Masters and his research team discovered the compound could prevent upregulation of CD14, a key inflammatory protein. The discovery was recently published in EBioMedicine. At a glance Researchers have uncovered a drug-like compound that blocks a key inflammatory pathway, involving the immune cell protein CD14. In the laboratory, the compound reduced CD14 levels, limiting […]

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Research

Vitamin D regulates calcium in intestine differently than previously thought

The findings have important implications on how bowel disease, including ulcerative colitis and Crohn's disease, may disrupt calcium regulation.

In a healthy person, the body absorbs calcium to maintain strong bones and perform other important functions like helping muscles move and nerves carry messages between the brain and body parts. Vitamin D is critical for this calcium absorption from the intestine and for the function of the intestine. The study, published in the journal […]

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Personal Story

Teen’s Crohn’s treatment helps her keep playing music

Posted: December 1 2020

For Abigail Tucker, it started with migraines and stomach pains. Then she started losing weight — as much as 50 pounds. She said her condition worsened to the point that, when she was 13, she felt like withdrawing from friends and skipping activities such as playing or teaching piano. Soon she was often missing a […]

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News

Severe form of inflammatory bowel disease linked to mouth bacteria

Posted: November 9 2020

Severe ulcerative colitis – a form of inflammatory bowel disease (IBD) – has been linked to a newly-discovered strain of oral bacteria, a study led by UNSW Sydney has found. Scientists have discovered a molecule called ‘pSma1’ in bacterial cell samples from people with severe ulcerative colitis. The molecule was found in some strains of […]

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News

Early, tight control of Crohn’s disease may have lasting benefits

Posted: October 26 2020

Early approaches to treatment of Crohn’s disease followed a step-up algorithm in which the newer medications would only be used if the patient did not benefit from established therapies. This sequential approach — termed step therapy — has more recently been called into question, as studies have repeatedly shown that the newer drugs for Crohn’s […]

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News

Cure found for rare form of inflammatory bowel disease

Posted: October 18 2020

The disease, called G6PC3 deficiency, affects around one in a million people and causes inflammation of the bowel, as well as lung infections. The team also showed that in affected patients, white blood cells called neutrophils trigger inflammation when exposed to gut bacteria, despite treatment with commonly available biological therapies. The patients were treated at the Royal […]

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News

Team develops wearable sensor to help those with inflammatory bowel disease

Posted: October 12 2020

University of Texas at Dallas researchers have designed a wearable device that monitors sweat for biomarkers that could signal flare-ups of inflammatory bowel disease (IBD). A team of bioengineers demonstrated the wristwatch-like device in a proof-of-concept study funded by the Crohn’s & Colitis Foundation and published online July 28 and in the October print edition […]

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Research

Cell therapy designed to treat inflammatory bowel disease

The research by the UPV/EHU-University of the Basque Country, in collaboration with Harvard University, has yielded highly encouraging results, and studies in animal models have already begun

The UPV/EHU’s NanoBioCel research group has for many years been developing systems enabling cells to be used as drugs. Cell therapy raises hopes for treating those diseases for which there are as yet no effective pharmacological solutions. Biomaterials, a leading journal in the field of materials sciences and medicine, has just published the paper ‘Multifunctional […]

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News

Blueberry compound may provide new inflammatory bowel disease therapy

Posted: October 5 2020

They believe it can provide a potential therapeutic option for chronic inflammatory diseases, including inflammatory bowel disease (IBD). The team, led by Chiharu Nishiyama, PhD, published its study “Pterostilbene reduces colonic inflammation by suppressing dendritic cell activation and promoting regulatory T cell development” in The FASEB Journal. The compound is similar to another phytocompound known to […]

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