BPA risk factor for inflammatory bowel disease?
BPA risk factor for inflammatory bowel disease
A recent study in a preclinical model of inflammatory bowel disease shows dietary exposure to bisphenol-A, or BPA, found in polycarbonate plastics and epoxy resins, can increase mortality and worsen its symptoms.
Dr. Clint Allred, a Texas A&M AgriLife researcher in the nutrition and food science department at Texas A&M University in College Station, led a study recently published in the Experimental Biology and Medicine journal.
“This is the first study to show that BPA can negatively impact gut microbial amino acid metabolism in a way that has been associated with irritable bowel disease,” said Jennifer DeLuca, a graduate student in the nutrition and food science department and first author for the study.
Also participating on the study were Dr. Kimberly Allred, also with the nutrition and food science department, and Rami Menon, a chemical engineer in the department of chemical engineering at Texas A&M.
Irritable bowel disease, or IBD, is a complex collection of diseases that include ulcerative colitis and Crohn’s disease. There is chronic inflammation of the digestive tract, and symptoms related to IBD can include severe diarrhea, abdominal pain, fatigue and weight loss. More serious instances can require lifelong treatment or possibly surgery.
“While the causes of IBD have not yet been determined, environmental exposures such as diet, smoking, infections, altered gut microbiome and toxins or pollutants are risk-factors for development and relapse,” Allred said. “In this study, we wanted to focus on what effect BPA may have on IBD.”
BPA is found in polycarbonate plastics often used in making containers to store food and beverages, such as water bottles. It is also found in epoxy resins used to coat the inside of metal products, such as food cans, bottle tops and water supply lines. In addition, some dental sealants and composites contain BPA.
Allred said research has previously shown BPA can seep into food or beverages from containers made with it and may have possible health effects on the behavior, the brain and prostate glands of fetuses, infants and children.
Read the full story on www.sciencedaily.com