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About Crohn’s Disease

Crohn’s disease is a chronic inflammatory condition that most commonly affects the last segment of the small intestine (ileum) and the first part of the large intestine (caecum), although it can occur in any part of the GIT from the mouth to the anus. It is not uncommon for people with Crohn’s disease to have normal, healthy parts of tissue in between areas of inflammation. This has implications for how Crohn’s disease is treated, especially by surgery. Also, unlike ulcerative colitis, where the inflammation is limited to the innermost lining of the intestinal wall, in Crohn’s disease the inflammation can extend into the deeper layers, which can lead to the development of complications that are quite specific to the condition.

How does Crohn’s disease affect the intestines?

Crohn’s disease affects the GI tract, and the intestinal wall becomes inflamed (red and swollen). The inflammation can penetrate through all layers of the GI tract and may occur at one or more locations in the GI tract, from the mouth right through to the anus, with areas of normal tissue between areas of diseased tissue. Depending on the main areas of the intestine involved in Crohn’s disease, the condition can be referred to as:

  • Ileocolitis: involves the ileum and colon (small and large intestine)
  • Ileitis: involves the ileum only (small intestine only)
  • Crohn’s (granulomatous) colitis: involves the colon only (large intestine only)
  • Gastroduodenal Crohn’s disease: involves the stomach and duodenum (small intestine)
  • Jejunoileitis: involves the jejunum (small intestine only)

Additional Information:

The latest news and Research

Personal Story

How the Expectation for Men to Be Tough Affected My Crohn’s Disease

Posted: March 22 2019

Boys are tough; boys don’t cry; boys play football. Pain is not something a boy experiences unless he is mortally wounded. Tough it out. Another child of many millions growing up with a gendered brain. Afraid of myself, my own emotions. Afraid of expressing weakness and pain. We’ve shamed the admittance of pain and idolized […]

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Research

Link Between Celiac Disease and Inflammatory Bowel Disease

Previous studies report a possible association between IBD and celiac disease; however, this link is controversial.

Using the search terms “inflammatory bowel disease” and “celiac disease,” researchers identified initially 1525 publications. In total 27 studies met inclusion criteria. Proportions and 95% confidence intervals (CIs) for the prevalence of IBD in celiac disease and vice versa were compared with published prevalence rates for the respective geographic regions. It was concluded that the […]

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Personal Story

Woman with Crohn’s disease ‘learned to love’ her scars

Posted: March 13 2019

Natalie who has Crohn’s disease has asked photographers not to remove her scars from pictures when she works as a model. Now she wants to encourage others to be body positive. Watch her story at https://www.bbc.com/news/av/uk-england-wiltshire-47495346/woman-with-crohn-s-disease-learned-to-love-her-scars

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News

Low-calorie ‘fasting-mimicking’ diet has potential to treat people with IBD

Posted: March 13 2019

What if a special diet could reduce inflammation and repair your gut? USC researchers provided evidence that a low-calorie “fasting-mimicking” diet has the potential to do just that. Published in the March 5 edition of Cell Reports, the study reports on the health benefits of periodic cycles of the diet for people with inflammation and indicated […]

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News

Dandruff could be a crucial factor in Crohn’s disease

Posted: March 13 2019

A fungus linked to dandruff may be a crucial factor driving the chronic stomach condition Crohn’s disease, according to a new study. Malassezia yeasts found in oily skin and scalp follicles are linked to skin conditions, including dandruff. Researchers discovered that the fungus commonly found in human hair follicles also resides in the gut. In […]

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Research

Potential new therapy for Crohn’s, colitis identified

Alternative to anti-inflammatory therapies reduces IBD symptoms in mice

Researchers have found a compound that may treat inflammatory bowel disease without directly targeting inflammation. The compound tamps down the activity of a gene linked to blood clotting. They discovered that the gene was turned on at sites of intestinal inflammation and damage, and blocking its activity reduces IBD symptoms in mice. The findings, published […]

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