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Research

Organoid-based regenerative medicine for inflammatory bowel disease

Recent advance in stem cell biology has added intestinal stem cells (ISCs) as a new player in this field.

The treatment of IBD has dramatically improved in the past decade, mainly by the outstanding clinical effect of biologic agents such as anti-TNF-α antibodies [3]. Those therapies were targeted mostly to control the inflammation that arises at the mucosa of IBD patients. However, less attention had been paid to the recovery of the tissue damage […]

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News

5 major advances in inflammatory bowel disease (IBD) treatment

Posted: January 30 2020

Lymphoma not associated with anti-TNF therapy in pediatric IBD patients Anti-tumor necrosis factor (aTNF) drugs are among the most effective medications used to treat pediatric IBD. Despite their effectiveness, concerns regarding an association with lymphoma limit their use in everyday practice. Based on a large, geographically diverse administrative insurance claims database of 9,284 pediatric IBD […]

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News

Human Body-on-Chip platform enables in vitro prediction of drug behaviors in humans

Posted: January 30 2020

Drug development is an extremely arduous and costly process, and failure rates in clinical trials that test new drugs for their safety and efficacy in humans remain very high. According to current estimates, only 13.8% of all tested drugs demonstrate ultimate clinical success and obtain approval by the Food and Drug Administration (FDA). There are […]

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News

To help IBD symptoms, target your microbiome with these foods

Posted: January 28 2020

A recent study on a new diet called the IBD-AID diet has shown that it may help. The diet focuses on correcting gut bacteria balance with probiotic and prebiotic foods. “Diet has a huge impact for IBD,” said Dr. David L. Suskind, a gastroenterologist with Seattle Children’s Hospital. He wasn’t involved in the research, but currently studies how […]

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Research

A brief history of human disease genetics

A primary goal of human genetics is to identify DNA sequence variants that influence biomedical traits, particularly those related to the onset and progression of human disease.

Genetic discoveries have substantially improved our understanding of the mechanisms responsible for many rare and common diseases and driven development of novel preventative and therapeutic strategies. Medical innovation will increasingly focus on delivering care tailored to individual patterns of genetic predisposition. Main For almost all human diseases, individual susceptibility is, to some degree, influenced by genetic […]

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Personal Story

Crohn’s disease dragged my body to a point where it barely functioned

Posted: January 23 2020

Today, I am healthier than I have been in a long time. But even so, this summer break alone has seen me in hospital twice to have abscesses removed, an outpatient flexible sigmoidoscopy​, which is an exam to evaluate the lower part of the large intestine, and an MRI. The days are dwindling until the first […]

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News

What anyone with ulcerative colitis needs to know about colorectal cancer

Posted: January 23 2020

Having a chronic illness like ulcerative colitis affects your health in so many ways, from the daily issues, like terrible pain, to the big picture, like an increased risk of colorectal cancer. The connection between ulcerative colitis and colorectal cancer can be scary and confusing, but it’s an important one to understand. Here’s what you need to know […]

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Research

Adding curcumin to mesalamine may benefit patients with ulcerative colitis

Adjunctive therapy with curcumin was found to provide a greater clinical benefit than placebo in patients with ulcerative colitis (UC) being treated with mesalamine.

To investigate the potential antiinflammatory properties of curcumin, study authors searched various databases (PubMed, EMBASE, Google Scholar, SCOPUS, and Web of Science databases) to obtain randomized controlled trials assessing its use as combination therapy in the treatment of mild to moderate UC. “The outcomes assessed were the pooled odds of clinical response and remission as well […]

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News

Investigational hyperbaric oxygen therapy (HBOT) indications: inflammatory bowel disease

Posted: January 23 2020

The recent HBOT experience HBOT for ulcerative colitis Until this point, all of the papers have concerned advanced CD, and none have combined UC cases in the mix. Pagoldh et al. designed a prospective, randomized, open-label clinical trial for HBOT intervention and UC, published in 2013. The primary objective of the study was to assess effects […]

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Research

Anti-inflammatory effects of abdominal vagus nerve stimulation on experimental intestinal inflammation

Electrical stimulation of the cervical vagus nerve is an emerging treatment for inflammatory bowel disease (IBD).

A growing body of evidence has demonstrated that unilateral electrical stimulation of the left cervical vagus nerve is a feasible treatment in a rodent model of colitis (Meregnani et al., 2011; Sun et al., 2013). Following chemically-induced colitis in rats, cervical vagus nerve stimulation (VNS) improved the disease activity index (DAI: weight and stool quality), decreased […]

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