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Systematic review with meta-analysis: comparative efficacy of biologics for induction and maintenance of mucosal healing in Crohn’s disease and ulcerative colitis controlled trial


Author: A Cholapranee, G. S Hazlewood, G. G. Kaplan, L. Peyrin-Biroulet, A. N. Ananthakrishnan

In 2017 researchers (A. Cholapranee, G. S Hazlewood, G. G. Kaplan, L. Peyrin-Biroulet, A. N. Ananthakrishnan) performed a meta-analysis of randomised controlled trials to check the effectiveness of mucosal healing as an endpoint of immunosuppressives, anti-tumour necrosis factor α (anti-TNF) or anti-integrin monoclonal antibody therapy for moderate-to-severe CD or UC.

The study concluded that the Anti-TNF and anti-integrin biological agents are successful in promoting mucosal healing in ulcerative colitis. This being said adalimumab is considered inferior to infliximab or methods using combination therapy. However in the case of Crohn’s disease the resulting benefits we similar.

View source: http://onlinelibrary.wiley.com/doi/10.1111/apt.14030/abstract
Author: A Cholapranee, G. S Hazlewood, G. G. Kaplan, L. Peyrin-Biroulet, A. N. Ananthakrishnan

Crohn’s and Colitis Australia would like to thank Wiley Online Library for permission to use this article.

Posted on: February 23 2018

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