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Systematic review with meta-analysis: comparative efficacy of biologics for induction and maintenance of mucosal healing in Crohn’s disease and ulcerative colitis controlled trial

Author: A Cholapranee, G. S Hazlewood, G. G. Kaplan, L. Peyrin-Biroulet, A. N. Ananthakrishnan

In 2017 researchers (A. Cholapranee, G. S Hazlewood, G. G. Kaplan, L. Peyrin-Biroulet, A. N. Ananthakrishnan) performed a meta-analysis of randomised controlled trials to check the effectiveness of mucosal healing as an endpoint of immunosuppressives, anti-tumour necrosis factor α (anti-TNF) or anti-integrin monoclonal antibody therapy for moderate-to-severe CD or UC.

The study concluded that the Anti-TNF and anti-integrin biological agents are successful in promoting mucosal healing in ulcerative colitis. This being said adalimumab is considered inferior to infliximab or methods using combination therapy. However in the case of Crohn’s disease the resulting benefits we similar.

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Author: A Cholapranee, G. S Hazlewood, G. G. Kaplan, L. Peyrin-Biroulet, A. N. Ananthakrishnan

Crohn’s and Colitis Australia would like to thank Wiley Online Library for permission to use this article.

Posted on: February 23 2018

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Good article. I certainly appreciate this site. Continue the good work!

I was very interested in the article "Good Vs bad bacteria - the bugs responsible for Crohn's disease". I was diagnosed with IBD 6 months ago and after a very bad reaction to Pentasa (but unproven) I was told to wait and try again when the symptoms peaked again. However, I started taking Probiotics each day and (touch wood) I have been in remission for 5 months, with high hopes. I am very interested in the research in this field.

My 16 year old daughter was diagnosed with UC in July 2016 and after 4 flare ups within 12 months and trying different medications, she was prescribed infliximab. This has been the miracle medication for her and am so thankful that she has been able to return to a "relatively normal life", enjoying school and her passion for sports again (bar 8 weekly visits to PMH for inflixmab infusions, routine colonoscopies and mezzaline daily). I had very little knowledge of UC and autoimmunie disease for that matter; and was shellshocked at how debilitating it can be. We are so grateful to have a wonderful gastro and medical team supporting my daughter and of course the impact that inflixmab has had; however know it is still early days and don't want to take anything for granted.

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