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Photoacoustic endoscopy could improve Crohn’s disease treatment


Better view of intestinal changes could lead to targeted treatments and fewer adverse effects

A newly developed endoscope could give doctors a better view of intestinal changes caused by Crohn’s disease. This additional information would help improve treatment of the painful and debilitating form of inflammatory bowel disease, which currently affects hundreds of thousands of U.S. adults.

Researchers from the University of Michigan describe the new device in The Optical Society (OSA) journal Biomedical Optics Express. The endoscope is used for photoacoustic imaging, a relatively new biomedical imaging method that uses light to produce sound waves in tissue that can be captured with ultrasound imaging.

“This new imaging technology could help more accurately plan therapy for each Crohn’s disease patient,” said Guan Xu, leader of the research team. “This would allow more targeted treatment and help minimize any adverse effects that might result from treatment.”

In Crohn’s disease, both inflammation and fibrosis cause the development of strictures — areas of narrowing — in the intestines. Although strictures caused by inflammation can be treated with drugs, the ones caused by fibrosis must be removed surgically.

“Currently, there is no imaging modality that can be used in the intestine to distinguish inflammation from fibrosis,” said Xu. “The difficulty in accurately assessing the presence and development of fibrosis in the strictures adds a great deal of complexity to Crohn’s disease management decisions.”

Read full article at https://www.sciencedaily.com/releases/2019/04/190424112919.htm

Posted on: April 28 2019

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