Onset of inflammatory bowel disease in adulthood tied to higher mortality
At the same time, IBD-related deaths have declined over time as a result of improving treatments.
Using the Swedish National Patient Register, the Karolinska Institutet identified patients who had developed inflammatory bowel disease (IBD), such as ulcerative colitis or Crohn’s disease, in adulthood between the years 1964 and 2014. Thanks to the Swedish civic registration number system, they were then able to cross-reference the disease data with the cause of death registry and study IBD-related mortality in over 80,000 patients – both in the entire patient population and in patients who had been diagnosed with IBD after the age of 60, a sub-group for which there has been a lack of detailed mortality data.
The results for this older group were little different from those for the entire patient sample. Patients who had developed IBD in adulthood or after the age of 60 were found to have a 50 per cent higher mortality than people without IBD, which corresponds to a shortened life expectancy of 2.3 years.
“Cardiovascular disease and cancer are the most common causes of death in the population as a whole, and here there is no difference between IBD patients and Swedes in general,” he continues. “But it seems as though the mortality of IBD patients is higher for a number of different diseases.”
At the same time, they were also able to show that IBD-related deaths have declined over time.
“This is very good news,” says Dr Olén. “Treatments for IBD, both medical and surgical, have improved greatly over the past 20 years due not least to the introduction of immunomodulating and biological drugs. It is one of our future goals as researchers to identify treatments that have a great protective effect.”
Read full article at https://www.news-medical.net/news/20190520/Onset-of-inflammatory-bowel-disease-in-adulthood-tied-to-higher-mortality.aspx and report at https://gut.bmj.com/content/early/2019/05/15/gutjnl-2018-317572