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Mechanisms by which Stress Affects the Experimental and Clinical Inflammatory Bowel Disease (IBD): Role of Brain-Gut Axis


By Brzozowski, Bartosz; Mazur-Bialy, Agnieszka

Researchers have conducted a study to investigate the effect of stress on inflammatory bowel disease, which has seen to alter a so called “braingut axis”; reflecting changes in cortrophin releasing hormone, mast cells activity, neurotransmission at the atomic nerves system and intestinal barrier function. The appearance of chronic stress has been linked to the increase in permeability of the intestinal wall, leading to an increase in bacterial translocation. This increased prevalence in bacteria in the colonic tissue in addition to a suppressed immune system can lead to a negative impact on IBD.

View Source Article: Mechanisms by which Stress Affects the Experimental and Clinical Inflammatory Bowel Disease (IBD): Role of Brain-Gut Axis

Posted on: February 23 2018

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Good article. I certainly appreciate this site. Continue the good work!

I was very interested in the article "Good Vs bad bacteria - the bugs responsible for Crohn's disease". I was diagnosed with IBD 6 months ago and after a very bad reaction to Pentasa (but unproven) I was told to wait and try again when the symptoms peaked again. However, I started taking Probiotics each day and (touch wood) I have been in remission for 5 months, with high hopes. I am very interested in the research in this field.

My 16 year old daughter was diagnosed with UC in July 2016 and after 4 flare ups within 12 months and trying different medications, she was prescribed infliximab. This has been the miracle medication for her and am so thankful that she has been able to return to a "relatively normal life", enjoying school and her passion for sports again (bar 8 weekly visits to PMH for inflixmab infusions, routine colonoscopies and mezzaline daily). I had very little knowledge of UC and autoimmunie disease for that matter; and was shellshocked at how debilitating it can be. We are so grateful to have a wonderful gastro and medical team supporting my daughter and of course the impact that inflixmab has had; however know it is still early days and don't want to take anything for granted.


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