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Could Viruses Attacking The Microbiome Be Responsible For Inflammatory Bowel Disease?


New research published in Nature Microbiology suggests that viruses called phages, which infect gut bacteria may be important in controlling the disease.

New research done in a mouse model of inflammatory bowel disease (IBD) has suggested that viruses called phages, which have the ability to infect and kill gut bacteria, may be involved in the disease.

The possible role of the microbiome in inflammatory diseases has been a busy area of research recently, with a study in May showing that gut bacteria may play a role in multiple sclerosis. The relationship between bacteria in the gut microbiome and IBD is an active area of research, but new research published in Nature Microbiology yesterday suggests that viruses called phages, which infect gut bacteria may be important in controlling the disease.

“Phage numbers are elevated at the intestinal mucosal surface and increase in abundance during inflammatory bowel disease, suggesting that phages play an unidentified role in IBD,” said  Breck Duerkop, lead author of the paper from the Department of Immunology and Microbiology at the University of Colorado School of Medicine.

Duerkop and colleagues used a mouse model of colitis and then did DNA sequencing to identify phages found in the gut as well as measuring how they changed when inflammation occurred. They then compared this information to that found in publicly available databases showing that the same phages were found in people with IBD.

“What we see in mice is consistent with what we see in humans with IBD. If we can better understand how these viruses shape bacterial communities, we might be able to determine how these contribute to the disease,” said Duerkop.

Read the full article at www.forbes.com

 

Posted on: August 6 2018

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This is the first study to show that BPA can negatively impact gut microbial amino acid metabolism in a way that has been associated with irritable bowel disease   Jennifer DeLuca, first author for the study By the way! The best essay writing service - https://www.easyessay.pro/

Good article. I certainly appreciate this site. Continue the good work!

I was very interested in the article "Good Vs bad bacteria - the bugs responsible for Crohn's disease". I was diagnosed with IBD 6 months ago and after a very bad reaction to Pentasa (but unproven) I was told to wait and try again when the symptoms peaked again. However, I started taking Probiotics each day and (touch wood) I have been in remission for 5 months, with high hopes. I am very interested in the research in this field.

My 16 year old daughter was diagnosed with UC in July 2016 and after 4 flare ups within 12 months and trying different medications, she was prescribed infliximab. This has been the miracle medication for her and am so thankful that she has been able to return to a "relatively normal life", enjoying school and her passion for sports again (bar 8 weekly visits to PMH for inflixmab infusions, routine colonoscopies and mezzaline daily). I had very little knowledge of UC and autoimmunie disease for that matter; and was shellshocked at how debilitating it can be. We are so grateful to have a wonderful gastro and medical team supporting my daughter and of course the impact that inflixmab has had; however know it is still early days and don't want to take anything for granted.


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