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Healthiest gut bacteria with plant-based or Mediterranean diet

Posted: October 21 2019

The study included four different groups of people: the population at large; people suffering from the chronic intestinal inflammatory disorder called Crohn’s disease; people with another similar gut disorder called ulcerative colitis; and people with irritable bowel syndrome (IBS). This helped them describe the individual’s microbial pattern. This was then correlated with the results of […]

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Fetal gut has more well-developed immune capabilities than previously thought

Posted: October 17 2019

Liza Konnikova and her colleagues applied advanced cellular and genomic analyses to study the makeup of the immune system in gut tissues from 14- to 23-week-old fetuses and infants undergoing surgery to correct gut defects. “We were surprised to find that almost complete immune capacity in the gut had developed as early as 14 weeks, […]

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Crohn’s disease study identifies genetic variant with potential to personalise treatment

Posted: October 10 2019

A UK wide collaboration led by the University of Exeter, Royal Devon & Exeter NHS Foundation Trust and the Wellcome Sanger Institute, has demonstrated that a genetic variant carried by 40% of the population explains why some patients develop antibodies against the anti-TNF drugs, infliximab and adalimumab and lose response. The authors conclude that a […]

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Genetic data now available for bacteria central to Crohn’s disease

Posted: October 10 2019

By studying a surgically removed, damaged bowel from a patient, researchers were able to culture bacteria from a special form of microscopic lesions that they earlier discovered and that can be present within the gut wall of the inflamed bowel in Crohn’s disease. After growing the bacteria in their laboratory, they chose one representative species, and performed a complete genome sequence […]

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When blood vessels are overly permeable

Posted: October 9 2019

Diseases in humans are often caused by malfunctioning cells. Epithelium cells, which form the barrier between the bowel and surrounding tissue, and inflammatory cells have been the focus of investigations of the mechanisms of chronic inflammatory diseases of the bowel up to now. While it is well known that inflammatory cells can only reach the […]

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Scientists find timekeepers of gut’s immune system

Posted: October 9 2019

As people go through their daily and nightly routines, their digestive tracts follow a routine, too: digesting food and absorbing nutrients during waking hours, and replenishing worn-out cells during sleep. Shift work and jet lag can knock sleep schedules and digestive rhythms out of whack. Such disruptions have been linked to increased risk of intestinal […]

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Nanotechnology in the Treatment of Inflammatory Bowel Disease

Particles, in the size of nanometres, can be used to deliver medications directly to the area of inflammation thus avoiding drug-associated systemic side effects.

To date, there is no cure for IBD, and therapy is aimed to achieve and maintain remission from inflammatory episodes. Inflammatory bowel disease treatment currently consists of anti-inflammatory agents such as 5-aminosalicylates (5-ASAs), corticosteroids, immunosuppressants, and biologic agents such as tumor necrosis factor alpha (TNF-α) antagonists, anti-interleukins, and anti-integrins.6 These drugs can induce and maintain remission; […]

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FODMAPs diet relieves symptoms of inflammatory bowel disease

Posted: October 3 2019

In a paper published today in Gastroenterology a team of researchers carried out a trial of a diet low in fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAP) in patients with IBD, experiencing persistent gut symptoms despite gut inflammation being under control. They found that a four-week low FODMAP diet improved certain gut symptoms such as swelling of […]

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Q&A: VARSITY, UNIFI add to the armamentarium for ulcerative colitis

Posted: October 1 2019

Two trials – the VARSITY and UNIFI trials – published in The New England Journal of Medicine on Wednesday helped to provide information about which therapies might be beneficial to patients with UC and in what circumstances. The UNIFI trial, which was previously presented at both the United European Gastroenterology Week and Digestive Disease Week, demonstrated that two […]

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Teamwork Makes the Dream Work: IBD Stem Cell Therapy Needs Us All

Posted: October 1 2019

The narrative surrounding the development of stem cell therapy for the treatment of inflammatory bowel disease was best said by Amy Lightner, MD, when she noted that we as gastroenterologists and colorectal surgeons are still in the early phases of navigating this therapy. However, the most obvious use of stem cells in IBD seems to be […]

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