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Research

Research

Kids with gut problems need mental health support

Childhood-onset IBD tends to have an even more severe disease course and longer duration than IBD diagnosed in adulthood.

We found that individuals with childhood-onset IBD were at increased risk of any psychiatric disorder and suicide attempt, including several categories of psychiatric disorders. Most of this association remained significant when comparing individuals with IBD with their siblings without IBD, thus accounting for environmental and genetic factors shared within siblings.  Our findings confirm and further […]

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New method to study Crohn’s disease microbes

Posted: August 21 2019

Identifying species among plants and animals has been a full-time occupation for some biologists, but the task is even more daunting for the myriad microbes that inhabit the planet. Now, MIT researchers have developed a simple measurement of gene flow that can define ecologically important populations among bacteria and archaea, including pinpointing populations associated with […]

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Personalised medicine and genetics

Scientists have identified specific links between genes and some diseases as well as between genes and the effectiveness of some medicines or treatments.

Many of us wonder why some people develop cancer while others do not and why a medication might work well for one person but be less effective or cause serious side effects in another. Although these differences are due to a number of important factors such as age, weight and lifestyle, our genetic make-up also […]

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Walnuts show ability to protect against Ulcerative colitis

Walnuts contain a complex array of natural compounds and phytochemicals that exhibit a wide range of health benefits, including protection against inflammation and colon cancer.

Dietary supplementation with nuts has shown a variety of health benefits. Among the tree nuts, walnuts (Juglans regia) contain the highest levels of the omega-3 fatty acid, namely alpha-linoleic acid (ALA), with the most favorable ratio of omega-3:omega-6 fatty acids (1:4.2) [1]. Walnuts also contain a large number of phytochemicals, including phenolic antioxidants, and high […]

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Smoking and ulcerative colitis

Posted: August 9 2019

Because smokers are less likely to develop ulcerative colitis (UC), a type of inflammatory bowel disease, patients with UC may be tempted to start smoking to lessen their symptoms. Researchers found no beneficial effects of smoking, however, in a nationwide study that included 6,754 patients with UC. Read full article at https://www.news-medical.net/news/20190807/Study-evaluates-the-effect-of-smoking-status-on-disease-outcomes-in-ulcerative-colitis.aspx

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Potential new treatment target for Crohn’s disease

Posted: August 9 2019

Fabio Cominelli, MD, professor of medicine at the School of Medicine and chief of gastroenterology at University Hospitals Cleveland Medical Center, led a three-year study, published recently in Cellular and Molecular Gastroenterology and Hepatology, focusing on the chronic inflammation that occurs in genetically susceptible individuals with CD. Using mouse models of CD, Cominelli and his team […]

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Editing of gut bacteria reduces cancer in mice with colitis

Posted: August 3 2019

Researchers have found that editing of the genes of the bacteria present in the guts of mice could help reduce the inflammation and associated risk of colorectal cancers. The research from the UT Southwestern scientists has been published this week in the latest issue of the Journal of Experimental Medicine. The study is titled, “Editing of […]

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How do Interactions between Gut Bacteria and Fungi Exacerbate Crohn’s Disease?

Posted: July 27 2019

Scientists have known that bacteria in the gut, along with environmental and genetic factors, contribute to the debilitating intestinal ailment of Crohn’s disease (CD). But in 2016, Mahmoud A Ghannoum, PhD, FAAM, FIDSA, professor and director of the Center for Medical Mycology at Case Western Reserve School of Medicine and University Hospitals Cleveland Medical Center, […]

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Crohn’s Disease Remission with a Plant-Based Diet: A Case Report

Posted: July 8 2019

In November 2014, a 25-year-old-male presented to the Department of Gastroenterology at a secondary care facility after having experienced several months of weight loss, diarrhea, and flu-like symptoms. He had a past medical history of peri-anal abscess and was on no prescribed or over-the-counter medications. He was a non-smoker. Ileo-colonoscopy demonstrated moderately inflamed mucosa with […]

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New study helps develop treatments targeting inflammation without affecting gut function

Posted: June 28 2019

A new Crick-led study in Immunity has characterized these distinct populations, which could help scientists to develop treatments targeting inflammation while preserving healthy gut function. These two populations are akin to worker and soldier ants, playing different roles depending on their context. The ‘worker ant’ population of immune cells is found naturally in the gut and helps […]

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