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Investigating the human intestinal mucus barrier up-close and personal

Posted: December 5 2019

We have a mutualistic but complicated relationship with the collection of microbes in our gut, known as the intestinal microbiome. This complex community of bacteria breaks down different food components, and releases nutrients such as vitamins and a plethora of other factors that control functions in tissues way beyond the intestinal tract. However, the sheer […]

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Mental health diagnoses common in IBD, but may be lessening in veterans

Posted: December 3 2019

“The aim of this study was to identify temporal trends in incidence and prevalence of these mental health problems, including anxiety, depression and PTSD in this population of veteran patients with IBD,” they wrote. “Identifying these comorbid mental health problems within this patient population would improve health care practices by helping providers streamline appropriate treatment […]

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Research

Remission in Crohn’s disease and relapses

People with Crohn’s disease (CD) in remission do not exhibit an improvement in gut microbiota composition, which might trigger relapses.

The present study investigated the dysbiosis and mucins production in CD patients during remission. Crohn’s disease (CD) is characterized by chronic inflammation of the gastrointestinal (GI) tract, and is associated with an increase in the production of inflammatory cytokines, such as interleukins (IL) and tumor necrosis factor alpha (TNF-α)1. The disease involves complex interactions among […]

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Research

A restoration ecology perspective on the treatment of inflammatory bowel disease

The human gut can be considered an ecosystem comprised of a community of microbes and nonliving components.

Chronic diseases are increasingly associated with disruption of this ecosystem. The science of restoration ecology was developed to restore degraded ecosystems, but its principles have not been applied widely to gut medicine, including the treatment of inflammatory bowel disease (IBD). One principle of ecological restoration is that “passive” restoration, which involves removing an ecosystem disturbance, […]

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Exposure to TNF inhibitors increases psoriasis risk in children with IBD, JIA

Posted: November 28 2019

The single-center study of electronic health record data from 2008 to 2018 included 4,403 children under 19 years at diagnosis, each with at least two ICD-9 or ICD-10 codes for JIA, IBD or chronic noninfectious osteomyelitis and at least two visits with a study center rheumatologist or gastroenterologist. Researchers defined TNF inhibitor exposure as at least […]

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Study finds associations between rheumatoid arthritis and other diseases before and after diagnosis

Posted: November 21 2019

The study, published in Mayo Clinic Proceedings, also found that people who have rheumatoid arthritis are at increased risk of developing heart disease, blood clots and sleep apnea. Comorbidities, or other chronic diseases or conditions, have been linked to poorer outcomes for patients with rheumatoid arthritis, including worsened physical disability, functional decline, poorer quality of life […]

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Inflammatory bowel disease appears to impact risk of Parkinson’s disease

Posted: November 20 2019

Relatively new research findings indicating that the earliest stages of Parkinson’s disease (PD) may occur in the gut have been gaining traction in recent years. In a review published in the Journal of Parkinson’s Disease, Tomasz Brudek, PhD, evaluates evidence for the association between inflammatory bowel disease (IBD) and PD and proposes directions for future research. “Parkinsonism is […]

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Could your gut influence fear responses in PTSD?

Posted: November 20 2019

For many years, mental disorders were simplistically understood as imbalances or deficits in the neurotransmitters in the brain. Recent research has debunked the “chemical imbalance” theory, and has given rise to more complex understandings around how the various systems of the body interact to influence physical and mental health. For example, many people are unaware that 95% […]

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Research

A high-sugar diet rapidly enhances susceptibility to colitis

The aim of this study was to identify the effect of a short-term diet high in sugar on susceptibility to colitis.

Most experimental findings relating to the ‘western diet’ and IBD have focused on high-fat content alone or in combination with high-sugar; thus the isolated effects of dietary refined sugars on enteric microbial composition, luminal milieu, and susceptibility to colitis are not well understood2. Population-based studies have demonstrated an association between intake of refined sugar and […]

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Research

Patients with ulcerative colitis and Crohn’s disease demonstrate increased risk for psychiatric illnesses

Individuals with ulcerative colitis (UC) or Crohn disease (CD) are more likely to have depression, anxiety, and bipolar disorder.

Patients with inflammatory bowel disease, including UC and CD, have been shown to be at increased risk for psychiatric illnesses, although most previous studies have had limited patient populations. The researchers retrospectively reviewed a large commercial database of information collected between 2013 and 2019 to better define the epidemiology of several psychiatric illnesses (depression, anxiety, bipolar […]

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