Skip to main content

Research

Research

Infants born to mothers with IBD present with altered gut microbiome

Prenatal and early life bacterial colonisation is thought to play a major role in shaping the immune system.

IBDs, comprising Crohn’s disease (CD) and UC, result from aberrant mucosal immune responses to bacteria in genetically susceptible individuals.1 2 While family history is the strongest risk factor for developing IBD, the genetic loci associated with risk do not fully explain disease heritability.1 IBD affects women during their reproductive years and 25% become pregnant after diagnosis. […]

Read more

Research

Tailoring treatment withdrawal in inflammatory bowel disease

Patients may not relapse over mid-term and those who have relapsed may have benefited from a drug-free period before being treated again.

There is currently no cure for inflammatory bowel disease. Most recent treatments and treatment strategies allow for healing intestinal lesions and maintaining steroid-free remission in a subset of patients. These patients and their doctors often ask themselves whether the treatment could be withdrawn. Several studies in both Crohn’s disease and ulcerative colitis have demonstrated a […]

Read more

News

“There’s a lot more work to be done.” – Aida Habtezion

Posted: January 9 2020

In the beginning of her career at Stanford, Habtezion was a fellow in the lab of Eugene Butcher, MD (professor, pathology). “Being in Dr. Eugene Butcher’s lab, learning about leukocyte trafficking, I became interested in why patients with ulcerative colitis would have their disease limited to the colon. Would leukocytes have specific things that targeted them to the […]

Read more

Research

Systemic inflammatory protein profiles distinguish IBS and ulcerative colitis,

Potential links between inflammation and IBS-like symptoms in these patient groups are still unclear.

Patients with ulcerative colitis (UC), a chronic inflammatory bowel disease (IBD) involving the colonic mucosa, may suffer from irritable bowel syndrome (IBS)–like symptoms during periods of remission. It has been suggested that UC patients experiencing IBS-like symptoms during remission suffer from inadequately treated inflammation.1 Likewise, there are reports of systemic and intestinal low-grade immune activation in […]

Read more

News

Your genes suck at predicting your health

Posted: January 7 2020

A new study this month is the latest to suggest that our genes really don’t do much to predict our health, at least most of the time. The study, published in PLOS One, is a review of the science surrounding genome-wide association studies (GWASs). These are studies that look at the genes of thousands, even millions of […]

Read more

News

Psychologists essential to address gut-brain link in IBD treatment

Posted: January 7 2020

Deakin Associate Professor of Psychology Antonina Mikocka-Walus said the data showed it was essential psychologists be included in routine care for those with IBD, increasingly recognised as a disorder of the gut-brain axis. As part of her research, published recently in two sister papers in the Internal Medicine Journal and JGH Open, Associate Professor Mikocka-Walus surveyed 731 Australians […]

Read more

Research

Altering intestinal microbiota

Researchers develop approach to alter intestinal microbiota and vaccinate against chronic inflammatory diseases

Targeted immunisation against bacterial flagellin, a protein that forms the appendage that enables bacterial mobility, can beneficially alter the intestinal microbiota, decreasing the bacteria’s ability to cause inflammation and thus protecting against an array of chronic inflammatory diseases, according to a new study by the Institute for Biomedical Sciences and the Neuroscience Institute at Georgia […]

Read more

Research

Review and implications of traditional Indian medicine for inflammatory bowel disease

Two classes of Ayurvedic formulation, fermented preparations and Ghrita are employed for the maintenance of intestinal disorders.

The current mainstream management of IBD includes antibiotics, corticosteroids, thiopurines, anti-tumor necrosis factor (TNF) antibodies, and aminosalicylates [2]. They have severe side effects such as diarrhea, nausea, vomiting, headache, and osteoporosis when used for the long term. The Indian System of Medicine which mainly comprises of Ayurveda (meaning the science of life) is one of the […]

Read more

News

Specialised immune cells could help repair inflammatory bowel disease damage in children

Posted: December 17 2019

“This study offers new hope for kids with IBD who urgently need new treatments by showing that Tr1 cells have the potential to reverse the damage caused by IBD,” said senior author Dr. Megan Levings, an investigator and head of the Childhood Disease Research Theme at BC Children’s and a professor in UBC’s department of […]

Read more

News

Living hydrogel can help heal intestinal wounds

Posted: December 17 2019

IBD patients suffer from pain, extreme discomfort, and numerous other symptoms caused by continuously relapsing and remitting inflammatory lesions in the layer of cells that lines the intestinal lumen (mucosa). The exact causes for IBD still are poorly understood, but it is clear that a misdirected immune system is at work, and that certain components […]

Read more