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New study helps develop treatments targeting inflammation without affecting gut function

Posted: June 28 2019

A new Crick-led study in Immunity has characterized these distinct populations, which could help scientists to develop treatments targeting inflammation while preserving healthy gut function. These two populations are akin to worker and soldier ants, playing different roles depending on their context. The ‘worker ant’ population of immune cells is found naturally in the gut and helps […]

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Research

Mass cytometry distinguishes between Crohn’s disease and Ulcerative colitis

Identification of better markers using less invasive methods would enable earlier diagnosis as well as improved monitoring and treatment of both diseases.

CD and UC can be distinguished clinically by disease location (UC is restricted to the colon, while CD can involve any part of the gastrointestinal tract) and disease phenotype (stricturing or penetrating can indicate CD), using endoscopy and imaging5. However, gathering this information can be invasive and costly, and still up to 20% of IBD […]

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News

Cannabis use in inflammatory bowel disease: new surveys announced

Posted: June 18 2019

Inflammatory Bowel Disease (IBD) is an umbrella term describing chronic and relapsing inflammatory diseases of the gastrointestinal tract, including ulcerative colitis and Crohn’s disease. Affected individuals experience abdominal pain, weight loss, diarrhoea and bleeding with a high risk of developing colorectal and small bowel cancers. It is a debilitating condition that often significantly affects a […]

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Daily pill containing gut bacteria from healthy people may help fight incurable conditions

Posted: May 27 2019

Bacteria taken from the faeces of healthy people could be used to treat Alzheimer’s, Parkinson’s and cancer, researchers claim. They hope the bacteria could one day replace potent drugs and treatments such as chemotherapy, which can cause a host of unwanted side effects. British scientists have now started the first trial to test whether taking […]

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Research

Estrogen receptor mediates anti-inflammatory action in Crohn’s disease

Accumulating evidence highlights the meaningful impact of estrogen receptors in physiology and pathophysiology of the colon.

Crohn’s disease (CD) is one of the inflammatory bowel disease (IBD) types characterized by chronic intestine inflammation. Although intestinal microbiota has been identified as the main factor responsible for immune response alternation in the past decade, other factors involved in CD pathogenesis, such as genetic and environmental, have been described. Etiology of CD is still […]

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News

Innovative ‘gut-on-a-chip’ technology will help better understand Crohn’s disease

Posted: May 5 2019

To model human health and disease, organ-on-a-chip technology mimics the human body’s organ structure, functionality and physiology in a controlled environment. For 10 years, Hyun Jung Kim, a biomedical engineering assistant professor in the Cockrell School of Engineering at The University of Texas at Austin and assistant professor in the Department of Oncology in UT’s […]

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News

Photoacoustic endoscopy could improve Crohn’s disease treatment

Posted: April 28 2019

A newly developed endoscope could give doctors a better view of intestinal changes caused by Crohn’s disease. This additional information would help improve treatment of the painful and debilitating form of inflammatory bowel disease, which currently affects hundreds of thousands of U.S. adults. Researchers from the University of Michigan describe the new device in The […]

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News

You’re Covered in Fungi. How Does That Affect Your Health?

Posted: April 13 2019

That’s one mystery that scientists are trying to unravel with research into the fungi that live in your gut. While the bacteria that colonize our intestines have been a scientific focus for more than a decade, the fungal critters there are starting to get more attention. Already, these studies have uncovered striking connections between fungi […]

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News

Damaged mitochondria and chronic inflammatory conditions

Posted: April 13 2019

Using mouse models, the researchers found that removing damaged mitochondria prevented the acute inflammation seen in diseases such as gout, as well as the chronic inflammation seen in the genetic disease Muckle-Well Syndrome. Inflammation is a protective process that the body uses to remove invading organisms or irritants, but too much inflammation can damage healthy cells […]

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News

Researchers explore nontoxic IBD treatment

Posted: April 4 2019

Inflammatory bowel disease (IBD), as well as other gastrointestinal problems, are characterized by impaired function in the intestinal epithelial barrier. Damage of the epithelial barrier has links to disease, but it is still unclear what causes impairments in this necessary defense layer. Nevertheless, research has shown that an enzyme called the myosin light chain kinase (MLCK) plays a […]

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