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Crohn’s Disease

News

Gutsy effort to produce comprehensive study of intestinal gases

Posted: September 18 2019

A source of embarrassment to some, or pure comedy to others, flatulence and the gases of the intestines are increasingly seen as playing an important role in our digestive health. A paper led by UNSW Sydney and published in Nature Reviews Gastroenterology & Hepatology has examined all available literature on gastrointestinal gases, their interactions with the microbiome […]

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News

Putting an end to inflammation

Posted: September 18 2019

Physician Dr. Andreas Ramming from Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) has succeeded in securing research funding in one of the toughest European selection processes. Over the next five years, the European Research Council (ERC) will support his outstanding research project with an ERC Starting Grant of 1.5 million euros. Dr. Andreas Ramming from the Department of Medicine […]

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Research

Scientists discover promising new lead in Crohn’s disease

QIMR Berghofer researchers have identified a key driver of the aggressive gut disorder, Crohn’s disease, a finding that could eventually lead to new treatments for the often-debilitating condition.

Crohn’s disease – also known as inflammatory bowel disease – is incurable and affects about 35,000 people in Australia. QIMR Berghofer scientists found the protein PD-L2 was overactive in people with Crohn’s disease. The study was led by the head of the Molecular Immunology group, Dr Michelle Wykes, and Dr Graham Radford-Smith, who leads the […]

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Personal Story

Student with stoma accused of taking drugs

Posted: September 11 2019

Amber Davies, 21, from Builth Wells, has a stoma after being diagnosed with ulcerative colitis aged 13. While on a night out in Birmingham, she was “grabbed” by a bouncer after coming out of the disabled toilet. Wetherspoons said staff apologised for the “confusing situation”. Amber posted an open letter on her Instagram account detailing her experience, saying the […]

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Research

Diet-induced remission of Crohn’s disease associated with altered microbial community structure

Researchers from the University of Pennsylvania looked at the association of diet, gut microbiome and IBD.

Background The microbiome has been implicated in the initiation and persistence of inflammatory bowel disease. Despite the fact that diet is one of the most potent modulators of microbiome composition and function and that dietary intervention is the first-line therapy for treating pediatric Crohn’s disease, the relationships between diet-induced remission, enteropathy, and microbiome are poorly […]

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News

Serotonin and anti-depressants can have a major effect on the gut’s microbiota

Posted: September 11 2019

Serotonin — a neurotransmitter, or chemical messenger that sends messages among cells — serves many functions in the human body, including playing a role in emotions and happiness. An estimated 90% of the body’s serotonin is produced in the gut, where it influences gut immunity. The team — led by senior author Elaine Hsiao and […]

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News

As CBD skyrockets in popularity, scientists scramble to understand how it’s metabolized

Posted: September 11 2019

In November of 2017, scientists at a subsidiary of Artelo Biosciences in Manchester, UK, tasked an intern with compiling any scientific study published on the body’s absorption, distribution and metabolism of cannabidiol. The company hoped to treat stroke with the compound, which is derived from the cannabis plant and commonly known as CBD, and this […]

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News

Exploring the impact of gut bacteria on gut health

Posted: September 3 2019

The human gastrointestinal tract is colonized by large numbers of bacteria, most of which are harmless and have a beneficial effect on normal body functions. Certain bacteria, however, can become dangerous and cause disease – but not in everybody. A new Emmy-Noether Independent Junior Research Group – led by Dr. Michael Sigal of Charité’s Medical Department, […]

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News

Drug Resistance Signature Discovered in Crohn’s Disease

Posted: September 3 2019

The study analyzed biopsy samples of inflamed and uninflamed Crohn’s disease lesions on small intestine tissue as soon as it was removed from patients. Researchers used single-cell RNA sequencing and CyTOF technology to look into the intestinal lesions in real time on a single- cellular level, identifying the immune cells and circulating blood cells and […]

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Personal Story

‘Running through ulcerative colitis literally saved my life’

Posted: September 3 2019

For many runners with chronic illnesses, managing their condition in order to continue doing the sport they love can be a challenge. But the benefits they gain from it—a calmer mind, a reduction in stress, for instance—help motivate them to keep pushing forward. But for 37-year-old Annabelle Winters, running through chronic illness hasn’t just given her […]

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